Property Summary

NCBI Gene PubMed Count 27
PubMed Score 21.60
PubTator Score 5.58

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count P-value
malignant mesothelioma 3163 1.14040151905194E-6
group 3 medulloblastoma 2254 1.25628552551285E-5
medulloblastoma, large-cell 6234 0.0241517799690767
Disease Target Count Z-score Confidence
fructose-1,6-bisphosphatase deficiency 8 3.143 1.6


Accession P63211 A4D1H2 O43835 Q08447 Q16026 Q6LCP6
Symbols GNG1


  Ortholog (8)

Gene RIF (8)

25916507 Suggest Gbeta4gamma1 as a modulator of M3 muscarinic receptor signaling.
25675501 PhLP1 binding stabilizes the Gbeta fold, disrupting interactions with CCT and releasing a PhLP1-Gbeta dimer for assembly with Ggamma.
23954591 During corticogenesis, a cilium-transduced, noncanonical IGF-1R-Gbetagamma-phospho(T94)Tctex-1 signaling pathway promotes the proliferation of neural progenitors through modulation of ciliary resorption and G1 length.
22065575 WDR26 is a novel Gbetagamma-binding protein that is required for the efficacy of Gbetagamma signaling and leukocyte migration
20048162 Gbetagamma subunits enter in a protein complex with activated Rap1a and its effector Radil; this complex is required downstream of receptor stimulation for the activation of integrins and the positive modulation of cell-matrix adhesiveness.
17548351 Gbetagamma mediates UVB-induced human keratinocyte apoptosis by augmenting the ectodomain shedding of HB-EGF, which sequentially activates EGFR and p38
17110384 G protein betagamma subunits stimulate type V and VI adenylyl cyclases
15901556 Observational study of genotype prevalence. (HuGE Navigator)

AA Sequence

CVIS                                                                       71 - 74

Text Mined References (27)

PMID Year Title
25916507 2015 G?4?1 as a modulator of M3 muscarinic receptor signalling and novel roles of G?1 subunits in the modulation of cellular signalling.
25675501 2015 Structures of the G?-CCT and PhLP1-G?-CCT complexes reveal a mechanism for G-protein ?-subunit folding and G?? dimer assembly.
25416956 2014 A proteome-scale map of the human interactome network.
23954591 2013 IGF-1 activates a cilium-localized noncanonical G?? signaling pathway that regulates cell-cycle progression.
22424883 2012 Genome-wide association study of lung function decline in adults with and without asthma.
22065575 2011 The WD40 repeat protein WDR26 binds G?? and promotes G??-dependent signal transduction and leukocyte migration.
20048162 2010 G protein betagamma subunits regulate cell adhesion through Rap1a and its effector Radil.
17548351 2007 G Protein betagamma subunits augment UVB-induced apoptosis by stimulating the release of soluble heparin-binding epidermal growth factor from human keratinocytes.
17185339 2007 Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins.
17110384 2007 Conditional stimulation of type V and VI adenylyl cyclases by G protein betagamma subunits.