Property Summary

NCBI Gene PubMed Count 46
PubMed Score 71.11
PubTator Score 70.41

Knowledge Summary


No data available


  Disease Sources (4)

Disease Target Count
Psychotic Disorders 20
Disease Target Count P-value
oligodendroglioma 2849 5.52208608917714E-16
posterior fossa group A ependymoma 1511 5.91018843705016E-16
lung carcinoma 2844 6.58070496796353E-14
atypical teratoid / rhabdoid tumor 4369 7.14967708882963E-14
pilocytic astrocytoma 3086 3.72203290166802E-12
non-small cell lung cancer 2798 1.05255695189148E-9
Breast cancer 3099 4.32549340076457E-8
medulloblastoma 1524 1.98230351439429E-7
medulloblastoma, large-cell 6234 6.15429517551012E-7
adult high grade glioma 2148 9.90146122930163E-7
lung cancer 4473 1.71389637644433E-6
glioblastoma 5572 6.36729590005392E-6
ulcerative colitis 2087 3.79886496362982E-5
primitive neuroectodermal tumor 3031 8.49213591276079E-5
interstitial cystitis 2299 1.69294255962793E-4
psoriasis 6685 3.16170038787469E-4
cystic fibrosis 1670 0.00156202152139977
astrocytoma 1493 0.0017889820405735
colon cancer 1475 0.00206139796019534
active Crohn's disease 918 0.00216046900950866
Atopic dermatitis 944 0.00338363195877516
subependymal giant cell astrocytoma 2287 0.00426988685094275
Pick disease 1893 0.00694823672367741
osteosarcoma 7933 0.00981588740268126
ovarian cancer 8492 0.019361557049339
esophageal adenocarcinoma 737 0.0195207517873976
Hydrolethalus syndrome 128 0.0233723282571146
adrenocortical carcinoma 1427 0.0246570190908442
severe Alzheimer's disease 49 0.0346776218914271
Parkinson's disease 364 0.0354252226684836
Disease Target Count Z-score Confidence
Alzheimer's disease 644 3.612 1.8
Disease Target Count Z-score Confidence
Dementia 129 3.072 1.5
Schizophrenia 503 3.002 1.5


  Differential Expression (30)

Disease log2 FC p
astrocytoma -5.600 0.002
posterior fossa group A ependymoma -5.900 0.000
oligodendroglioma -4.500 0.000
esophageal adenocarcinoma -2.200 0.020
psoriasis 2.500 0.000
glioblastoma -5.800 0.000
osteosarcoma 1.809 0.010
medulloblastoma -5.800 0.000
atypical teratoid / rhabdoid tumor -7.100 0.000
medulloblastoma, large-cell -6.200 0.000
primitive neuroectodermal tumor -4.400 0.000
Atopic dermatitis 1.400 0.003
adrenocortical carcinoma -1.759 0.025
non-small cell lung cancer 2.467 0.000
Hydrolethalus syndrome -2.221 0.023
colon cancer 3.400 0.002
lung cancer 4.000 0.000
active Crohn's disease 1.745 0.002
Parkinson's disease -2.200 0.035
interstitial cystitis -1.700 0.000
cystic fibrosis 2.000 0.002
adult high grade glioma -6.000 0.000
pilocytic astrocytoma -6.100 0.000
subependymal giant cell astrocytoma -4.522 0.004
severe Alzheimer's disease -1.576 0.035
Breast cancer -1.900 0.000
lung carcinoma -2.000 0.000
Pick disease -3.400 0.007
ulcerative colitis 2.000 0.000
ovarian cancer 1.100 0.019


Accession P62760 D6W515 P28677 P29103 P42323 Q9UM20 VILIP
Symbols HLP3


  Ortholog (9)

Species Source
Chimp OMA EggNOG
Mouse OMA Inparanoid
Rat OMA Inparanoid
Horse OMA Inparanoid
Cow OMA Inparanoid
Chicken OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
Zebrafish OMA Inparanoid

Gene RIF (35)

26836160 These data indicate that VILIP-1 alone or in combination with other AD CSF biomarkers represent a valuable marker for the early diagnosis of AD, recognition of MCI patients at higher risk to develop dementia, and in differentiating AD from LBD.
26769253 These findings suggest a unique role for cerebrospinal fluid Vilip-1 as a biomarker of entorhinal cortex neuron loss in Alzheimer disease
26683098 Underexpression of VSNL1 is associated with glioblastoma multiforme.
25019684 Results show that in the presence of calcium, N-myristoylation significantly increases the kinetic rate of VILIP adsorption to the membrane.
24742816 We show for the first time that the C-terminus of VILIP-1, containing Cys187, might represent a novel redox-sensitive motif and that VILIP-1 dimerization and aggregation are hallmarks of amyotrophic lateral sclerosis
24075506 The results suggest that both serum and cerebrospinal fluid levels of VILIP-1 may be one of predictive markers of acute encephalopathy with biphasic seizures.
23800322 The results showed that the CSF VILIP-1 level had significantly increased in Alzheimer disease patients compared with both normal controls and Lewy body dementia patients.
22832524 VSNL1 single-nucleotide polymorphisms and pathological changes in VILIP-1 protein expression, possibly occurring during brain development, may contribute to the morphological and functional deficits observed in schizophrenia.
22357717 The findings suggest that CSF VILIP-1 and VILIP-1/Abeta42 predict rates of global cognitive decline similarly to tau and tau/Abeta42, and may be useful CSF surrogates for neurodegeneration in early Alzheimer disease.
22331379 VSNL1 may play a role in the pathophysiology of aldosterone-producing adenomas harboring mutations in the potassium channel KCNJ5 via its antiapoptotic function in response to calcium cytotoxicity and its effect on aldosterone production.

AA Sequence


Text Mined References (48)

PMID Year Title
26836160 2016 Predictive Value of Cerebrospinal Fluid Visinin-Like Protein-1 Levels for Alzheimer's Disease Early Detection and Differential Diagnosis in Patients with Mild Cognitive Impairment.
26769253 2016 Altered Levels of Visinin-Like Protein 1 Correspond to Regional Neuronal Loss in Alzheimer Disease and Frontotemporal Lobar Degeneration.
26683098 2016 Dysregulated miR-671-5p / CDR1-AS / CDR1 / VSNL1 axis is involved in glioblastoma multiforme.
25416956 2014 A proteome-scale map of the human interactome network.
25019684 2014 Specific interaction to PIP2 increases the kinetic rate of membrane binding of VILIPs, a subfamily of Neuronal Calcium Sensors (NCS) proteins.
24742816 2014 Dimerization of visinin-like protein 1 is regulated by oxidative stress and calcium and is a pathological hallmark of amyotrophic lateral sclerosis.
24075506 2014 Serum and cerebrospinal fluid levels of visinin-like protein-1 in acute encephalopathy with biphasic seizures and late reduced diffusion.
23800322 2013 CSF levels of the neuronal injury biomarker visinin-like protein-1 in Alzheimer's disease and dementia with Lewy bodies.
22832524 2011 Association of VSNL1 with schizophrenia, frontal cortical function, and biological significance for its gene product as a modulator of cAMP levels and neuronal morphology.
22357717 2012 CSF VILIP-1 predicts rates of cognitive decline in early Alzheimer disease.