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Tbio
DEFA1
Neutrophil defensin 1

Protein Summary
Description
Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382679
  • ENSP00000372126
  • ENSG00000206047
  • ENST00000382689
  • ENSP00000372136
  • ENSG00000240247
  • ENST00000382692
  • ENSP00000372139
  • ENST00000644528
  • ENSP00000496578
  • ENSG00000284983
  • ENST00000644617
  • ENSP00000496340
  • ENSG00000285176
  • ENST00000644834
  • ENSP00000496058
  • ENST00000645146
  • ENSP00000493747

Symbol
  • DEF1
  • DEFA2
  • MRS
  • HP1
  • MRS
  • DEF1
  • HP-1
  • DEFA2
  • HNP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.78
disease
0.56
cell line
0.46
tissue
0.37
biological term
0.35


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 206.19   (req: < 5)
Gene RIFs: 99   (req: <= 3)
Antibodies: 376   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 206.19   (req: >= 5)
Gene RIFs: 99   (req: > 3)
Antibodies: 376   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0