Tbio | Glucose-6-phosphate exchanger SLC37A1 |
Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.
The protein encoded by this gene localizes to the endoplasmic reticulum (ER) membrane. This protein translocates glucose-6-phosphate from the cytoplasm into the lumen of the ER for hydrolysis into glucose by another ER membrane protein. This gene is a member of the solute carrier 37 gene family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
The protein encoded by this gene localizes to the endoplasmic reticulum (ER) membrane. This protein translocates glucose-6-phosphate from the cytoplasm into the lumen of the ER for hydrolysis into glucose by another ER membrane protein. This gene is a member of the solute carrier 37 gene family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Comments
Disease | Target Count | P-value |
---|---|---|
pilocytic astrocytoma | 3086 | 1.28623426068181E-6 |
medulloblastoma, large-cell | 6234 | 1.84782024125022E-4 |
ductal carcinoma in situ | 1745 | 6.79485777912684E-4 |
intraductal papillary-mucinous neoplasm (IPMN) | 3289 | 0.00168970927955261 |
invasive ductal carcinoma | 2950 | 0.00256297938106269 |
intraductal papillary-mucinous carcinoma (IPMC) | 2988 | 0.00412910218209017 |
active ulcerative colitis | 477 | 0.015060225630505 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Glycerol kinase deficiency | 10 | 4.625 | 2.3 |
Glycogen storage disease | 37 | 3.77 | 1.9 |
Disease | log2 FC | p |
---|---|---|
medulloblastoma, large-cell | -1.500 | 0.000 |
intraductal papillary-mucinous carcinoma... | 1.400 | 0.004 |
intraductal papillary-mucinous neoplasm ... | 1.500 | 0.002 |
active ulcerative colitis | 1.312 | 0.015 |
pilocytic astrocytoma | -1.100 | 0.000 |
ductal carcinoma in situ | 1.500 | 0.001 |
invasive ductal carcinoma | 1.400 | 0.003 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Macaque | OMA EggNOG Inparanoid |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Dog | OMA EggNOG Inparanoid |
Horse | OMA EggNOG Inparanoid |
Cow | OMA EggNOG Inparanoid |
Pig | OMA EggNOG Inparanoid |
Opossum | OMA EggNOG Inparanoid |
Platypus | OMA EggNOG Inparanoid |
Chicken | OMA Inparanoid |
PMID | Text |
---|---|
21949678 | Data show that SLC37A1 and SLC37A2 are endoplasmic reticulum associated, P(i)-linked antiporters, that can transport glucose-6-phosphate. |
MARLPAGIRFIISFSRDQWYRAFIFILTFLLYASFHLSRKPISIVKGELHKYCTAWDEADVRFSSQNRKS 1 - 70 GSAAPHQLPDNETDCGWAPFDKNNYQQLLGALDYSFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAF 71 - 140 TALFGLGYFYNIHSFGFYVVTQVINGLVQTTGWPSVVTCLGNWFGKGRRGLIMGVWNSHTSVGNILGSLI 141 - 210 AGYWVSTCWGLSFVVPGAIVAAMGIVCFLFLIEHPNDVRCSSTLVTHSKGYENGTNRLRLQKQILKSEKN 211 - 280 KPLDPEMQCLLLSDGKGSIHPNHVVILPGDGGSGTAAISFTGALKIPGVIEFSLCLLFAKLVSYTFLFWL 281 - 350 PLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYIFSTVSKMGLE 351 - 420 ATIAMLLLSGALVSGPYTLITTAVSADLGTHKSLKGNAHALSTVTAIIDGTGSVGAALGPLLAGLLSPSG 421 - 490 WSNVFYMLMFADACALLFLIRLIHKELSCPGSATGDQVPFKEQ 491 - 533 //
PMID | Year | Title |
---|---|---|
21949678 | 2011 | SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters. |
19946888 | 2010 | Defining the membrane proteome of NK cells. |
16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |
15862967 | 2005 | Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin. |
14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. |
11112347 | 2000 | Cloning and characterization of a putative human glycerol 3-phosphate permease gene (SLC37A1 or G3PP) on 21q22.3: mutation analysis in two candidate phenotypes, DFNB10 and a glycerol kinase deficiency. |
10830953 | 2000 | The DNA sequence of human chromosome 21. |