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  5. Glucose-6-phosphate exchanger SLC37A1

Tbio Glucose-6-phosphate exchanger SLC37A1

Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.

The protein encoded by this gene localizes to the endoplasmic reticulum (ER) membrane. This protein translocates glucose-6-phosphate from the cytoplasm into the lumen of the ER for hydrolysis into glucose by another ER membrane protein. This gene is a member of the solute carrier 37 gene family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

 Comments

Property Summary

NCBI Gene PubMed Count 7
PubMed Score 2.61
PubTator Score 2.20

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
pilocytic astrocytoma 3086 1.28623426068181E-6
medulloblastoma, large-cell 6234 1.84782024125022E-4
ductal carcinoma in situ 1745 6.79485777912684E-4
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00168970927955261
invasive ductal carcinoma 2950 0.00256297938106269
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00412910218209017
active ulcerative colitis 477 0.015060225630505
Disease Target Count Z-score Confidence
Glycerol kinase deficiency 10 4.625 2.3
Glycogen storage disease 37 3.77 1.9

Expression

  Differential Expression (7)

Disease log2 FC p
medulloblastoma, large-cell -1.500 0.000
intraductal papillary-mucinous carcinoma... 1.400 0.004
intraductal papillary-mucinous neoplasm ... 1.500 0.002
active ulcerative colitis 1.312 0.015
pilocytic astrocytoma -1.100 0.000
ductal carcinoma in situ 1.500 0.001
invasive ductal carcinoma 1.400 0.003

Synonym

Accession P57057 D3DSJ7 Q9HAQ1
Symbols G3PP

Gene

SLC37A1

PANTHER Protein Class (2)

  Ortholog (11)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG Inparanoid
Chicken OMA Inparanoid

 GO Function (1)

 GO Component (2)

 GO Process (3)

 Compartment GO Term (25)

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 HCA RNA Cell Line (55)

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Pathway (1)

 UniProt Keyword (11)

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Gene RIF (1)

PMID Text
21949678 Data show that SLC37A1 and SLC37A2 are endoplasmic reticulum associated, P(i)-linked antiporters, that can transport glucose-6-phosphate.

AA Sequence 

MARLPAGIRFIISFSRDQWYRAFIFILTFLLYASFHLSRKPISIVKGELHKYCTAWDEADVRFSSQNRKS      1 - 70
GSAAPHQLPDNETDCGWAPFDKNNYQQLLGALDYSFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAF     71 - 140
TALFGLGYFYNIHSFGFYVVTQVINGLVQTTGWPSVVTCLGNWFGKGRRGLIMGVWNSHTSVGNILGSLI    141 - 210
AGYWVSTCWGLSFVVPGAIVAAMGIVCFLFLIEHPNDVRCSSTLVTHSKGYENGTNRLRLQKQILKSEKN    211 - 280
KPLDPEMQCLLLSDGKGSIHPNHVVILPGDGGSGTAAISFTGALKIPGVIEFSLCLLFAKLVSYTFLFWL    281 - 350
PLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYIFSTVSKMGLE    351 - 420
ATIAMLLLSGALVSGPYTLITTAVSADLGTHKSLKGNAHALSTVTAIIDGTGSVGAALGPLLAGLLSPSG    421 - 490
WSNVFYMLMFADACALLFLIRLIHKELSCPGSATGDQVPFKEQ                               491 - 533
//

Text Mined References (7)

PMID Year Title
21949678 2011 SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters.
19946888 2010 Defining the membrane proteome of NK cells.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15862967 2005 Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
11112347 2000 Cloning and characterization of a putative human glycerol 3-phosphate permease gene (SLC37A1 or G3PP) on 21q22.3: mutation analysis in two candidate phenotypes, DFNB10 and a glycerol kinase deficiency.
10830953 2000 The DNA sequence of human chromosome 21.