| Tbio | Glucose-6-phosphate exchanger SLC37A1 |
Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.
The protein encoded by this gene localizes to the endoplasmic reticulum (ER) membrane. This protein translocates glucose-6-phosphate from the cytoplasm into the lumen of the ER for hydrolysis into glucose by another ER membrane protein. This gene is a member of the solute carrier 37 gene family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
The protein encoded by this gene localizes to the endoplasmic reticulum (ER) membrane. This protein translocates glucose-6-phosphate from the cytoplasm into the lumen of the ER for hydrolysis into glucose by another ER membrane protein. This gene is a member of the solute carrier 37 gene family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| Astrocytoma, Pilocytic | 3081 | 7.9e-07 |
| medulloblastoma, large-cell | 6241 | 1.8e-04 |
| ductal carcinoma in situ | 1745 | 6.8e-04 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 1.7e-03 |
| invasive ductal carcinoma | 2951 | 2.6e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 4.1e-03 |
| active ulcerative colitis | 764 | 1.5e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Glycerol kinase deficiency | 10 | 4.505 | 2.3 |
| Glycogen storage disease | 39 | 3.646 | 1.8 |
| Disease | log2 FC | p |
|---|---|---|
| active ulcerative colitis | 1.312 | 1.5e-02 |
| Astrocytoma, Pilocytic | -1.100 | 7.9e-07 |
| ductal carcinoma in situ | 1.500 | 6.8e-04 |
| intraductal papillary-mucinous carcinoma... | 1.400 | 4.1e-03 |
| intraductal papillary-mucinous neoplasm ... | 1.500 | 1.7e-03 |
| invasive ductal carcinoma | 1.400 | 2.6e-03 |
| medulloblastoma, large-cell | -1.500 | 1.8e-04 |
MARLPAGIRFIISFSRDQWYRAFIFILTFLLYASFHLSRKPISIVKGELHKYCTAWDEADVRFSSQNRKS 1 - 70 GSAAPHQLPDNETDCGWAPFDKNNYQQLLGALDYSFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAF 71 - 140 TALFGLGYFYNIHSFGFYVVTQVINGLVQTTGWPSVVTCLGNWFGKGRRGLIMGVWNSHTSVGNILGSLI 141 - 210 AGYWVSTCWGLSFVVPGAIVAAMGIVCFLFLIEHPNDVRCSSTLVTHSKGYENGTNRLRLQKQILKSEKN 211 - 280 KPLDPEMQCLLLSDGKGSIHPNHVVILPGDGGSGTAAISFTGALKIPGVIEFSLCLLFAKLVSYTFLFWL 281 - 350 PLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYIFSTVSKMGLE 351 - 420 ATIAMLLLSGALVSGPYTLITTAVSADLGTHKSLKGNAHALSTVTAIIDGTGSVGAALGPLLAGLLSPSG 421 - 490 WSNVFYMLMFADACALLFLIRLIHKELSCPGSATGDQVPFKEQ 491 - 533 //
