| Tbio | Myc-associated zinc finger protein |
May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors. Regulates inflammation-induced expression of serum amyloid A proteins.
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| HIV Infections | 102 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| breast carcinoma | 1638 | 3.3e-18 |
| osteosarcoma | 7950 | 1.2e-06 |
| psoriasis | 6694 | 4.2e-06 |
| medulloblastoma, large-cell | 6241 | 8.2e-06 |
| malignant mesothelioma | 3232 | 3.4e-05 |
| group 4 medulloblastoma | 1855 | 2.3e-04 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.4e-03 |
| glioblastoma | 5792 | 2.7e-03 |
| Polycystic ovary syndrome | 360 | 4.1e-03 |
| lung cancer | 4740 | 5.6e-03 |
| COPD | 118 | 5.8e-03 |
| Rheumatoid arthritis | 1191 | 2.3e-02 |
| Disease | log2 FC | p |
|---|---|---|
| atypical teratoid / rhabdoid tumor | 1.400 | 1.4e-03 |
| breast carcinoma | 1.200 | 3.3e-18 |
| COPD | -1.300 | 5.8e-03 |
| glioblastoma | 1.200 | 2.7e-03 |
| group 4 medulloblastoma | 1.900 | 2.3e-04 |
| lung cancer | 1.100 | 5.6e-03 |
| malignant mesothelioma | 1.100 | 3.4e-05 |
| medulloblastoma, large-cell | 2.100 | 8.2e-06 |
| osteosarcoma | -1.765 | 1.2e-06 |
| Polycystic ovary syndrome | -1.040 | 4.1e-03 |
| psoriasis | -3.200 | 4.2e-06 |
| Rheumatoid arthritis | -1.400 | 2.3e-02 |
MFPVFPCTLLAPPFPVLGLDSRGVGGLMNSFPPPQGHAQNPLQVGAELQSRFFASQGCAQSPFQAAPAPP 1 - 70 PTPQAPAAEPLQVDLLPVLAAAQESAAAAAAAAAAAAAVAAAPPAPAAASTVDTAALKQPPAPPPPPPPV 71 - 140 SAPAAEAAPPASAATIAAAAATAVVAPTSTVAVAPVASALEKKTKSKGPYICALCAKEFKNGYNLRRHEA 141 - 210 IHTGAKAGRVPSGAMKMPTMVPLSLLSVPQLSGAGGGGGEAGAGGGAAAVAAGGVVTTTASGKRIRKNHA 211 - 280 CEMCGKAFRDVYHLNRHKLSHSDEKPYQCPVCQQRFKRKDRMSYHVRSHDGAVHKPYNCSHCGKSFSRPD 281 - 350 HLNSHVRQVHSTERPFKCEKCEAAFATKDRLRAHTVRHEEKVPCHVCGKMLSSAYISDHMKVHSQGPHHV 351 - 420 CELCNKGTGEVCPMAAAAAAAAAAAAAAVAAPPTAVGSLSGAEGVPVSSQPLPSQPW 421 - 477 //
