Property Summary

NCBI Gene PubMed Count 19
PubMed Score 99.65
PubTator Score 97.22

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
lung cancer 4473 8.82051282503524E-4
ductal carcinoma in situ 1745 0.00614316046563804
invasive ductal carcinoma 2950 0.0125155206820101
Disease Target Count Z-score Confidence
Clubfoot 35 3.186 1.6
Shwachman-Diamond syndrome 16 3.139 1.6

Expression

  Differential Expression (3)

Disease log2 FC p
lung cancer 1.300 0.001
ductal carcinoma in situ 1.100 0.006
invasive ductal carcinoma 1.400 0.013

Synonym

Accession P53365 B4DX86 B4E306 D3DQT5
Symbols POR1

Gene

PANTHER Protein Class (2)

PDB

1I49   1I4D   1I4L   1I4T   4DCN  

  Ortholog (13)

Species Source
Chimp OMA EggNOG
Macaque OMA Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG
C. elegans OMA Inparanoid

Gene RIF (6)

PMID Text
26296658 The data indicate that arfaptin 2 is the first molecule to regulate NF-kappaB signaling by interacting with the functional IkappaB kinase complex but not by direct inhibiting IKKbeta phosphorylation.
23695357 The binding of arfaptin1, but not arfaptin2, to PI(4)P is regulated by protein kinase D (PKD) mediated phosphorylation at Ser100 within the AH.
23638170 both Arf1 activation and high membrane curvature are required for efficient recruitment of Arfaptin2 to membranes
22679020 The Arl1.Arfaptin-2 BAR structure suggests that one of the two Arl1 molecules competes with Rac1, which binds to the concave face of the Arfaptin-2 BAR homodimer and may hinder its membrane association.
15809304 arfaptin 2 phosphorylation at Ser260 by Akt inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment
11854752 arfaptin 2 is involved in regulating huntingtin protein aggregation

AA Sequence

MTDGILGKAATMEIPIHGNGEARQLPEDDGLEQDLQQVMVSGPNLNETSIVSGGYGGSGDGLIPTGSGRH      1 - 70
PSHSTTPSGPGDEVARGIAGEKFDIVKKWGINTYKCTKQLLSERFGRGSRTVDLELELQIELLRETKRKY     71 - 140
ESVLQLGRALTAHLYSLLQTQHALGDAFADLSQKSPELQEEFGYNAETQKLLCKNGETLLGAVNFFVSSI    141 - 210
NTLVTKTMEDTLMTVKQYEAARLEYDAYRTDLEELSLGPRDAGTRGRLESAQATFQAHRDKYEKLRGDVA    211 - 280
IKLKFLEENKIKVMHKQLLLFHNAVSAYFAGNQKQLEQTLQQFNIKLRPPGAEKPSWLEEQ             281 - 341
//

Text Mined References (26)

PMID Year Title
26296658 2015 Dimer of arfaptin 2 regulates NF-?B signaling by interacting with IKK?/NEMO and inhibiting IKK? kinase activity.
25468996 2014 E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
25416956 2014 A proteome-scale map of the human interactome network.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23695357 2013 Recruitment of arfaptins to the trans-Golgi network by PI(4)P and their involvement in cargo export.
23638170 2013 Arf1 and membrane curvature cooperate to recruit Arfaptin2 to liposomes.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22679020 2012 Structural basis for membrane binding specificity of the Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin-2 determined by Arl1 GTPase.
21988832 2011 Toward an understanding of the protein interaction network of the human liver.
21516116 2011 Next-generation sequencing to generate interactome datasets.
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