Property Summary

NCBI Gene PubMed Count 43
PubMed Score 21.45
PubTator Score 25.70

Knowledge Summary


No data available


  Disease Sources (1)

Disease Target Count P-value
non-small cell lung cancer 2798 1.38784338565781E-19
lung adenocarcinoma 2714 3.9840564608839E-8
ovarian cancer 8492 1.2784112532461E-6
acute quadriplegic myopathy 1157 3.33911243251191E-6
inflammatory breast cancer 404 6.5261310661889E-4
group 3 medulloblastoma 2254 7.08668760557333E-4
lung cancer 4473 0.00552160757220737
astrocytoma 1493 0.018121980360672
breast carcinoma 1614 0.0205372779580863


  Differential Expression (9)

Disease log2 FC p
astrocytoma 1.100 0.018
acute quadriplegic myopathy 1.151 0.000
non-small cell lung cancer 1.483 0.000
lung cancer 1.200 0.006
breast carcinoma 1.100 0.021
group 3 medulloblastoma 1.100 0.001
lung adenocarcinoma 1.100 0.000
inflammatory breast cancer 1.300 0.001
ovarian cancer 2.400 0.000


Accession P52298 B2RE91 B4DMK7 E9PAR5 Q14924 Q2TS50
Symbols CBC2



3FEX   3FEY   1H2T   1H2U   1H2V   1H6K   1N52   1N54  

  Ortholog (11)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG
Chicken OMA EggNOG
Anole lizard EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
C. elegans OMA EggNOG Inparanoid
Fruitfly EggNOG Inparanoid

Gene RIF (7)

26382858 NCBP2 is not required for cell viability and poly(A) RNA export.
21326824 A novel alternative splice variant of CBP20, termed CBP20S, has an in-frame deletion, leading to the translation of a protein lacking most of the RNA recognition motif (RRM).
19668212 determined how importin-beta binds to the cap-binding complex (CBC) through its CBP20 subunit
19648179 a new MIF4G domain-containing protein, CTIF (CBP80/20-dependent translation initiation factor) that interacts directly with CBP80 and is part of the CBP80/20-dependent translation initiation complex
17499042 We show that NELF interacts with the nuclear cap binding complex (CBC), a heterodimeric, multifunctional factor that plays important roles in several mRNA processing steps, and the two factors together participate in the 3' end processing of histone mRNAs
12434151 Structural basis of m7GpppG binding to the nuclear cap-binding protein complex.
12374755 crystal structure at 2.1 A resolution of CBP20 and CBP80 bound to an m(7)GpppG cap analogue

AA Sequence

DYDAGRGGYGKLAQNQ                                                          141 - 156

Text Mined References (53)

PMID Year Title
26496610 2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
26382858 2015 mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3.
25416956 2014 A proteome-scale map of the human interactome network.
24129315 2014 Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
22681889 2012 The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
22658674 2012 Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
22365833 2012 Dynamic protein-protein interaction wiring of the human spliceosome.
21326824 Binding properties and dynamic localization of an alternative isoform of the cap-binding complex subunit CBP20.