| Tchem | Ketohexokinase |
This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Fructosuria | 1 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Deficiency of fructokinase | 1 |
| Disease | Target Count | P-value |
|---|---|---|
| atypical teratoid / rhabdoid tumor | 5112 | 2.9e-07 |
| medulloblastoma, large-cell | 6241 | 3.3e-05 |
| medulloblastoma | 720 | 5.2e-05 |
| nephrosclerosis | 333 | 8.9e-04 |
| astrocytoma | 1146 | 2.5e-03 |
| lung cancer | 4740 | 3.1e-03 |
| adult high grade glioma | 3801 | 3.2e-03 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 6.9e-03 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| fructose-1,6-bisphosphatase deficiency | 7 | 5.323 | 2.7 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.100 | 3.2e-03 |
| astrocytoma | -1.100 | 2.5e-03 |
| atypical teratoid / rhabdoid tumor | -1.600 | 2.9e-07 |
| lung cancer | 1.200 | 3.1e-03 |
| medulloblastoma | -1.100 | 5.2e-05 |
| medulloblastoma, large-cell | -1.200 | 3.3e-05 |
| nephrosclerosis | -1.433 | 8.9e-04 |
| pancreatic ductal adenocarcinoma liver m... | -1.323 | 6.9e-03 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG |
CHEMBL2063927
pIC50 7.55
CHEMBL2017250
pIC50 7.64
CHEMBL1809168
pIC50 7.64
CHEMBL2017249
pIC50 7.75
CHEMBL2017242
pIC50 7.75
CHEMBL2017246
pIC50 7.80
CHEMBL2063925
pIC50 7.82
CHEMBL2017214
pIC50 7.92
CHEMBL2017251
pIC50 8.00
CHEMBL2017247
pIC50 8.01
CHEMBL2017253
pIC50 8.10
CHEMBL2017248
pIC50 8.15
CHEMBL2017244
pIC50 8.16
CHEMBL2063924
pIC50 8.70
MEEKQILCVGLVVLDVISLVDKYPKEDSEIRCLSQRWQRGGNASNSCTVLSLLGAPCAFMGSMAPGHVAD 1 - 70 FLVADFRRRGVDVSQVAWQSKGDTPSSCCIINNSNGNRTIVLHDTSLPDVSATDFEKVDLTQFKWIHIEG 71 - 140 RNASEQVKMLQRIDAHNTRQPPEQKIRVSVEVEKPREELFQLFGYGDVVFVSKDVAKHLGFQSAEEALRG 141 - 210 LYGRVRKGAVLVCAWAEEGADALGPDGKLLHSDAFPPPRVVDTLGAGDTFNASVIFSLSQGRSVQEALRF 211 - 280 GCQVAGKKCGLQGFDGIV 281 - 298 //
