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Tbio
MCAM
Cell surface glycoprotein MUC18

Protein Summary
Description
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264036
  • ENSP00000264036
  • ENSG00000076706

Symbol
  • MUC18
  • CD146
  • MUC18
  • HEMCAM
  • METCAM
  • MelCAM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
PubMedID
0.98
transcription factor perturbation
0.98
disease perturbation
0.96
disease
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1005.41   (req: < 5)
Gene RIFs: 178   (req: <= 3)
Antibodies: 1686   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1005.41   (req: >= 5)
Gene RIFs: 178   (req: > 3)
Antibodies: 1686   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0