| Tbio | L-serine dehydratase/L-threonine deaminase |
This gene encodes one of three enzymes that are involved in metabolizing serine and glycine. L-serine dehydratase converts L-serine to pyruvate and ammonia and requires pyridoxal phosphate as a cofactor. The encoded protein can also metabolize threonine to NH4+ and 2-ketobutyrate. The encoded protein is found predominantly in the liver. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Liver Cirrhosis, Experimental | 769 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| ependymoma | 4679 | 3.9e-07 |
| group 4 medulloblastoma | 1855 | 4.2e-07 |
| medulloblastoma, large-cell | 6241 | 3.3e-06 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.7e-05 |
| tuberculosis | 2010 | 2.1e-05 |
| primitive neuroectodermal tumor | 3035 | 3.6e-05 |
| adult high grade glioma | 3801 | 2.3e-04 |
| osteosarcoma | 7950 | 2.5e-04 |
| invasive ductal carcinoma | 2951 | 3.1e-04 |
| adrenocortical carcinoma | 1428 | 1.3e-02 |
| inflammatory breast cancer | 286 | 1.7e-02 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 1.7e-02 |
| adrenocortical adenoma | 131 | 3.3e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Autosomal dominant nonsyndromic deafness 69 | 4 | 5.326 | 2.7 |
| Sly syndrome | 4 | 3.442 | 1.7 |
| Hypervitaminosis A | 13 | 3.414 | 1.7 |
| late-onset retinal degenration | 12 | 3.081 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| adrenocortical adenoma | -1.108 | 3.3e-02 |
| adrenocortical carcinoma | -1.172 | 1.3e-02 |
| adult high grade glioma | -1.400 | 2.3e-04 |
| atypical teratoid / rhabdoid tumor | -1.300 | 1.7e-05 |
| ependymoma | -1.200 | 3.9e-07 |
| group 4 medulloblastoma | -1.600 | 4.2e-07 |
| inflammatory breast cancer | 1.300 | 1.7e-02 |
| invasive ductal carcinoma | 2.197 | 3.1e-04 |
| medulloblastoma, large-cell | -1.600 | 3.3e-06 |
| osteosarcoma | 1.013 | 2.5e-04 |
| pancreatic ductal adenocarcinoma liver m... | -2.132 | 1.7e-02 |
| primitive neuroectodermal tumor | -1.400 | 3.6e-05 |
| tuberculosis | -1.100 | 2.1e-05 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| OMA EggNOG |
MMSGEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRGIGHFCKRWAKQGCAHFVCSSAGNAGM 1 - 70 AAAYAARQLGVPATIVVPSTTPALTIERLKNEGATVKVVGELLDEAFELAKALAKNNPGWVYIPPFDDPL 71 - 140 IWEGHASIVKELKETLWEKPGAIALSVGGGGLLCGVVQGLQEVGWGDVPVIAMETFGAHSFHAATTAGKL 141 - 210 VSLPKITSVAKALGVKTVGAQALKLFQEHPIFSEVISDQEAVAAIEKFVDDEKILVEPACGAALAAVYSH 211 - 280 VIQKLQLEGNLRTPLPSLVVIVCGGSNISLAQLRALKEQLGMTNRLPK 281 - 328 //
