Protein Summary
GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance. This gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. Mutations in this gene are associated with Duane's retraction syndrome 2 (DURS2). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
- ENST00000295497
- ENSP00000295497
- ENSG00000128656
- ENST00000409156
- ENSP00000386470
- ENST00000409900
- ENSP00000386741
- ARHGAP2
- CHN
- NC
- CHN
- DURS2
- ARHGAP2
- RHOGAP2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor perturbation | 0.91 | ||
protein domain | 0.85 | ||
histone modification site profile | 0.84 | ||
kinase perturbation | 0.76 | ||
metabolite | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 86.84 (req: < 5)
Gene RIFs: 26 (req: <= 3)
Antibodies: 389 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 86.84 (req: >= 5)
Gene RIFs: 26 (req: > 3)
Antibodies: 389 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0