Property Summary

NCBI Gene PubMed Count 50
PubMed Score 98.55
PubTator Score 97.34

Knowledge Summary


No data available


  Disease Sources (4)

Disease Target Count P-value
lung carcinoma 2844 2.23149255777189E-36
non-small cell lung cancer 2798 1.34190081831852E-18
breast carcinoma 1614 7.75833915603142E-16
lung adenocarcinoma 2714 7.25235606388408E-14
pilocytic astrocytoma 3086 1.3586198188208E-9
ependymoma 2514 1.65139002752498E-9
group 4 medulloblastoma 1875 1.32477006368858E-8
ovarian cancer 8492 1.38743333955926E-8
Breast cancer 3099 3.18270846422511E-7
adult high grade glioma 2148 4.74785809047407E-7
lung cancer 4473 8.70154753363862E-7
pancreatic cancer 2300 1.19944000283351E-6
malignant mesothelioma 3163 2.2424283565612E-6
medulloblastoma, large-cell 6234 2.77074332100079E-6
glioblastoma 5572 3.21817652479755E-6
primitive neuroectodermal tumor 3031 9.95467627024043E-6
osteosarcoma 7933 2.08248191718658E-5
cystic fibrosis 1670 2.82371434078057E-5
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00154343599908636
gastric cancer 436 0.00407820799917925
active ulcerative colitis 477 0.00461680157158367
active Crohn's disease 918 0.00864039707154241
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0103195831919372
atypical teratoid/rhabdoid tumor 1095 0.0139707678230975
oligodendroglioma 2849 0.0193288793456714
mucosa-associated lymphoid tissue lymphoma 480 0.0268850515918389
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0280991344735971
colon cancer 1475 0.0296613900464839
astrocytic glioma 2241 0.0414404004405894
Disease Target Count Z-score Confidence
Rheumatoid Arthritis 1171 0.0 2.0
Disease Target Count Z-score Confidence
Cancer 2346 3.208 1.6



Accession P12429 B2R9W6 Q6LET2
Symbols ANX3



1AII   1AXN  

  Ortholog (10)

Gene RIF (21)

26475168 These results suggest that the iEA index or a combination of polymorphisms in EGFR and ANXA3 may serve as predictive factors of drug response, and therefore could be useful for optimal selection of chemotherapy regimens.
26116899 HIV-1 Vpr downregulates the expression of ANXA3 in human monocyte-derived dendritic cells
26095609 Our results suggest that ANXA3 can serve as a novel diagnostic biomarker and that the inhibition of ANXA3 may be a viable therapeutic option for the treatment of CD133+ liver-CSC-driven HCC.
26093083 ANX A3 has roles as a mammary biomarker, regulator and therapeutic target in breast cancer
25267273 findings suggest that ANXA3 plays a role in HCC CSC/CIC maintenance, and that ANXA3 may represent a potential CSC/CIC-specific therapeutic target for improving the treatment of HCC.
24954692 Two different antigenic variants of ANXA3 are present in post-DRE urines and their clinical significance for diagnosis of prostate cancer should be further investigated.
24884814 Urinary calreticulin, annexin A2, and annexin A3 are very likely a panel of biomarkers with potential value for upper tract urothelial carcinoma diagnosis.
24824926 Annexin A3 was upregulated in gastric cancer cells. Deletion of endogenous Annexin A3 significantly inhibited gastric cancer cell proliferation, migration, and invasion.
24815437 Expression of annexin A3 was increased in gastric cancer compared with that in normal gastric tissues. Annexin A3 expression was significantly associated with tumor volume and TNM stage.
24375474 Findings reveal that ANXA3 might play an important role in hepatocellular carcinoma progression and chemoresistance.

AA Sequence


Text Mined References (52)

PMID Year Title
26475168 2015 Construction of possible integrated predictive index based on EGFR and ANXA3 polymorphisms for chemotherapy response in fluoropyrimidine-treated Japanese gastric cancer patients using a bioinformatic method.
26095609 2015 ANXA3/JNK Signaling Promotes Self-Renewal and Tumor Growth, and Its Blockade Provides a Therapeutic Target for Hepatocellular Carcinoma.
26093083 2015 Annexin A3 is a mammary marker and a potential neoplastic breast cell therapeutic target.
25267273 2015 Annexin A3 as a potential target for immunotherapy of liver cancer stem-like cells.
24954692 2014 Prostate cancer biomarker annexin A3 detected in urines obtained following digital rectal examination presents antigenic variability.
24884814 2014 A panel of tumor markers, calreticulin, annexin A2, and annexin A3 in upper tract urothelial carcinoma identified by proteomic and immunological analysis.
24824926 2014 Impact of Annexin A3 expression in gastric cancer cells.
24815437 2014 Expression of annexin A3 in gastric cancer and its correlation with proliferation and apoptosis.
24529757 2014 Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
24375474 2015 Annexin A3 promotes tumorigenesis and resistance to chemotherapy in hepatocellular carcinoma.