Tbio P0DPB6 DNA-directed RNA polymerases I and III subunit RPAC2

Protein Summary

Description

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. The protein encoded by this gene is a component of the RNA polymerase I and RNA polymerase III complexes, which function in the synthesis of ribosomal RNA precursors and small RNAs, respectively. Mutations in this gene are a cause of Treacher Collins syndrome (TCS), a craniofacial development disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2011]

Uniprot Accession IDs

• P0DPB6
• Q5TBX2
• Q96BR3
• Q9Y2S0
• RNA polymerases I and III subunit AC2

Gene Name

• POLR1D

Ensembl ID

• ENST00000302979
• ENSP00000302478
• ENSG00000186184
• ENST00000647448
• ENSP00000495898

Symbol

• AC19
• RPA9
• TCS2
• RPA16
• RPAC2
• RPC16
• POLR1C
• RPO1-3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

PANTHER Classes

Protein / Transferase / Nucleotidyltransferase / Dna-directed Rna Polymerases I And Iii Subunit Rpac2

Protein / Nucleic Acid Binding / Rna Binding Protein / Dna-directed Rna Polymerase / Dna-directed Rna Polymerases I And Iii Subunit Rpac2

DTO Classes

Protein / Enzyme / Transferase / Nucleotidyltransferase / Polymerase / Dna-directed Rna Polymerase / Dna-directed Rna Polymerases I And Iii Subunit Rpac2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.3   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.3   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0