Property Summary

NCBI Gene PubMed Count 28
Grant Count 14
R01 Count 12
Funding $1,450,046.94
PubMed Score 46.54
PubTator Score 122.09

Knowledge Summary

Patent

No data available

Expression

Gene RIF (17)

PMID Text
26116899 HIV-1 Vpr upregulates the gene expression of IFIT2 in human monocyte-derived dendritic cells
25252956 HIV-1 Vpr upregulates the gene expression of IFIT2 in human monocyte-derived dendritic cells
25174799 Data shows that IFIT2 expression is downregulated in adenocarcinoma of gastric esophageal junction cells; its ectopic expression leads to cell apoptosis, suggesting its role as a tumor suppressor.
25170834 HIV-1 Vpr upregulates the gene expression of IFIT2 in human monocyte-derived dendritic cells
24742347 HIV-1 Vpr upregulates the gene expression of IFIT2 in human monocyte-derived dendritic cells
23867918 Data show that interferon-induced proteins with tetratricopeptide repeats 1 and 2 (IFIT1 and IFIT2) contribute to the regulation of hepatitis B virus (HBV) replication, likely at both transcriptional and posttranscriptional steps.
22986528 IFIT2, a protein responsible for interferon stimulation, may prevent oral squamous cell carcinoma (OSCC) metastasis and serve as a valuable prognostic marker.
22825553 ISG54 binds specifically to some RNAs, such as adenylate uridylate (AU)-rich RNAs, with or without 5' triphosphorylation.
22647704 HIV-1 Vpr upregulates the gene expression of IFIT2 in human monocyte-derived dendritic cells
22065572 Inhibitor of kappaB kinase epsilon (IKK(epsilon)), STAT1, and IFIT2 proteins define novel innate immune effector pathway against West Nile virus infection.
More...

AA Sequence

MSENNKNSLESSLRQLKCHFTWNLMEGENSLDDFEDKVFYRTEFQNREFKATMCNLLAYLKHLKGQNEAA      1 - 70
LECLRKAEELIQQEHADQAEIRSLVTWGNYAWVYYHMGRLSDVQIYVDKVKHVCEKFSSPYRIESPELDC     71 - 140
EEGWTRLKCGGNQNERAKVCFEKALEKKPKNPEFTSGLAIASYRLDNWPPSQNAIDPLRQAIRLNPDNQY    141 - 210
LKVLLALKLHKMREEGEEEGEGEKLVEEALEKAPGVTDVLRSAAKFYRRKDEPDKAIELLKKALEYIPNN    211 - 280
AYLHCQIGCCYRAKVFQVMNLRENGMYGKRKLLELIGHAVAHLKKADEANDNLFRVCSILASLHALADQY    281 - 350
EDAEYYFQKEFSKELTPVAKQLLHLRYGNFQLYQMKCEDKAIHHFIEGVKINQKSREKEKMKDKLQKIAK    351 - 420
MRLSKNGADSEALHVLAFLQELNEKMQQADEDSERGLESGSLIPSASSWNGE                      421 - 472
//

Text Mined References (31)

PMID Year Title
25174799 2014 MicroRNA-645, up-regulated in human adencarcinoma of gastric esophageal junction, inhibits apoptosis by targeting tumor suppressor IFIT2.
23867918 2014 Interferon-induced proteins with tetratricopeptide repeats 1 and 2 are cellular factors that limit hepatitis B virus replication.
23237964 2013 The broad-spectrum antiviral functions of IFIT and IFITM proteins.
22986528 2013 Depleting IFIT2 mediates atypical PKC signaling to enhance the migration and metastatic activity of oral squamous cell carcinoma cells.
22825553 2012 Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
22658674 2012 Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
22065572 2011 Inhibitor of ?B kinase epsilon (IKK(epsilon)), STAT1, and IFIT2 proteins define novel innate immune effector pathway against West Nile virus infection.
21642987 2011 IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA.
21190939 2011 The interferon stimulated gene 54 promotes apoptosis.
More...