Property Summary

NCBI Gene PubMed Count 28
PubMed Score 46.54
PubTator Score 122.09

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count
Influenza 142
Disease Target Count P-value
juvenile dermatomyositis 1189 1.13004833281798E-14
lung carcinoma 2844 3.9905926247806E-11
astrocytoma 1493 1.64079488740326E-7
pilocytic astrocytoma 3086 4.55404641157994E-7
lung cancer 4473 3.89245451792639E-6
primary Sjogren syndrome 789 1.02549838789422E-5
posterior fossa group A ependymoma 1511 4.06458080171774E-5
cutaneous lupus erythematosus 1056 1.21267982353063E-4
malignant mesothelioma 3163 1.23049409026235E-4
osteosarcoma 7933 1.26063857725274E-4
pancreatic cancer 2300 3.86357786289692E-4
medulloblastoma, large-cell 6234 4.1729028718715E-4
group 4 medulloblastoma 1875 9.37569279554225E-4
systemic lupus erythematosus 172 0.00123274649651686
progressive supranuclear palsy 674 0.00300849387321605
acute myeloid leukemia 785 0.00669124496253826
Multiple Sclerosis 498 0.00829800390462646
subependymal giant cell astrocytoma 2287 0.00900923275586192
pediatric high grade glioma 2712 0.00980140251607761
Breast cancer 3099 0.0102570828144352
active Crohn's disease 918 0.0102904948289129
invasive ductal carcinoma 2950 0.0109720538750369
cystic fibrosis 1670 0.0110218558372715
pancreatic carcinoma 567 0.0137482168087562
nasopharyngeal carcinoma 1056 0.0141877984995341
glioblastoma 5572 0.0220097125263264
mucosa-associated lymphoid tissue lymphoma 480 0.0241311251347741
urothelial carcinoma 318 0.0411155486530334

Expression

Synonym

Accession P09913 Q5T767 IFIT-2
Symbols P54
G10P2
IFI54
ISG54
cig42
IFI-54
IFIT-2
GARG-39
IFI-54K
ISG-54K
ISG-54 K

Gene

PDB

4G1T  

  Ortholog (6)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA Inparanoid
Cow OMA Inparanoid
Pig OMA Inparanoid

Gene RIF (17)

PMID Text
26116899 HIV-1 Vpr upregulates the gene expression of IFIT2 in human monocyte-derived dendritic cells
25252956 HIV-1 Vpr upregulates the gene expression of IFIT2 in human monocyte-derived dendritic cells
25174799 Data shows that IFIT2 expression is downregulated in adenocarcinoma of gastric esophageal junction cells; its ectopic expression leads to cell apoptosis, suggesting its role as a tumor suppressor.
25170834 HIV-1 Vpr upregulates the gene expression of IFIT2 in human monocyte-derived dendritic cells
24742347 HIV-1 Vpr upregulates the gene expression of IFIT2 in human monocyte-derived dendritic cells
23867918 Data show that interferon-induced proteins with tetratricopeptide repeats 1 and 2 (IFIT1 and IFIT2) contribute to the regulation of hepatitis B virus (HBV) replication, likely at both transcriptional and posttranscriptional steps.
22986528 IFIT2, a protein responsible for interferon stimulation, may prevent oral squamous cell carcinoma (OSCC) metastasis and serve as a valuable prognostic marker.
22825553 ISG54 binds specifically to some RNAs, such as adenylate uridylate (AU)-rich RNAs, with or without 5' triphosphorylation.
22647704 HIV-1 Vpr upregulates the gene expression of IFIT2 in human monocyte-derived dendritic cells
22065572 Inhibitor of kappaB kinase epsilon (IKK(epsilon)), STAT1, and IFIT2 proteins define novel innate immune effector pathway against West Nile virus infection.
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AA Sequence

MSENNKNSLESSLRQLKCHFTWNLMEGENSLDDFEDKVFYRTEFQNREFKATMCNLLAYLKHLKGQNEAA      1 - 70
LECLRKAEELIQQEHADQAEIRSLVTWGNYAWVYYHMGRLSDVQIYVDKVKHVCEKFSSPYRIESPELDC     71 - 140
EEGWTRLKCGGNQNERAKVCFEKALEKKPKNPEFTSGLAIASYRLDNWPPSQNAIDPLRQAIRLNPDNQY    141 - 210
LKVLLALKLHKMREEGEEEGEGEKLVEEALEKAPGVTDVLRSAAKFYRRKDEPDKAIELLKKALEYIPNN    211 - 280
AYLHCQIGCCYRAKVFQVMNLRENGMYGKRKLLELIGHAVAHLKKADEANDNLFRVCSILASLHALADQY    281 - 350
EDAEYYFQKEFSKELTPVAKQLLHLRYGNFQLYQMKCEDKAIHHFIEGVKINQKSREKEKMKDKLQKIAK    351 - 420
MRLSKNGADSEALHVLAFLQELNEKMQQADEDSERGLESGSLIPSASSWNGE                      421 - 472
//

Text Mined References (31)

PMID Year Title
25174799 2014 MicroRNA-645, up-regulated in human adencarcinoma of gastric esophageal junction, inhibits apoptosis by targeting tumor suppressor IFIT2.
23867918 2014 Interferon-induced proteins with tetratricopeptide repeats 1 and 2 are cellular factors that limit hepatitis B virus replication.
23237964 2013 The broad-spectrum antiviral functions of IFIT and IFITM proteins.
22986528 2013 Depleting IFIT2 mediates atypical PKC signaling to enhance the migration and metastatic activity of oral squamous cell carcinoma cells.
22825553 2012 Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
22658674 2012 Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
22065572 2011 Inhibitor of ?B kinase epsilon (IKK(epsilon)), STAT1, and IFIT2 proteins define novel innate immune effector pathway against West Nile virus infection.
21642987 2011 IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA.
21190939 2011 The interferon stimulated gene 54 promotes apoptosis.
More...