Property Summary

NCBI Gene PubMed Count 327
Grant Count 338
R01 Count 180
Funding $53,380,616.54
PubMed Score 786.90
PubTator Score 828.69

Knowledge Summary

Patent

No data available

Expression

Synonym

Accession P07355 Q567R4 Q6N0B3 Q8TBV2 Q96DD5 Q9UDH8
Symbols P36
ANX2
LIP2
LPC2
CAL1H
LPC2D
ANX2L4
PAP-IV
HEL-S-270

Gene

PDB

4DRW   4FTG   4HRH   1W7B   1XJL   2HYU   2HYV   2HYW  

Gene RIF (258)

PMID Text
26963384 the role of Axna2 is instructive for understanding the development of RA, suppress the effect of Axna2 might provide a new potential measure for treatment of RA.
26925708 annexin A2 and S100A10 expressions are powerful predictors of serous ovarian cancer outcome.
26797420 Suggest that ANX A2 plays an important role in aggressive breast tumor growth by regulating proteolytic pathways in the tumor microenvironment.
26632510 Data from studies using proteomic/microarray methods suggest ANXA2 (not ANXA5) plays important role in packaging of microRNAs into extracellular vesicles; this process appears independent of microRNA sequence and dependent on calcium signaling.
26547929 Data show that ONECUT2, IGF2BP1, and ANXA2 proteins were confirmed to be microRNA-9 (miR-9) targets and aberrantly upregulated in hepatocellular carcinoma (HCC).
26465153 These data show that disruption of ANX2/p11 interaction results in reduced ALL cell adhesion to osteoblasts, increased ALL cell sensitization to chemotherapy, and suppression of ALL cell homing and engraftment.
26438086 highly specific 30 kDa plant lectin could dissociate AnxA2 from endogenous lectin galectin-3 interaction at the cell surface. This dissociation could down-regulate Bcl-2 family proteins, cell proliferation, and migration simultaneously triggering cell apoptosis
26362938 Expression levels of ANXA2 and HE4 were closely related to the malignant biological behavior of endometrial carcinoma
26307676 Anxa2 binds to STAT3 and promotes epithelial to mesenchymal transition in breast cancer.
26272794 MIEN1, a novel interactor of Annexin A2, promotes tumor cell migration by enhancing AnxA2 cell surface expression
More...

AA Sequence

MSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQD      1 - 70
IAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQEL     71 - 140
QEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDV    141 - 210
PKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKG    211 - 280
KGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD               281 - 339
//

Text Mined References (335)

PMID Year Title
26963384 2016 The Annexin a2 Promotes Development in Arthritis through Neovascularization by Amplification Hedgehog Pathway.
26925708 2016 Annexin A2 and S100A10 are independent predictors of serous ovarian cancer outcome.
26797420 2016 Long-term efficacy and downstream mechanism of anti-annexinA2 monoclonal antibody (anti-ANX A2 mAb) in a pre-clinical model of aggressive human breast cancer.
26632510 2015 Commitment of Annexin A2 in recruitment of microRNAs into extracellular vesicles.
26547929 2015 Comprehensive profiling of novel microRNA-9 targets and a tumor suppressor role of microRNA-9 via targeting IGF2BP1 in hepatocellular carcinoma.
26465153 2015 Disruption of Annexin II /p11 Interaction Suppresses Leukemia Cell Binding, Homing and Engraftment, and Sensitizes the Leukemia Cells to Chemotherapy.
26438086 2016 Cell surface interaction of annexin A2 and galectin-3 modulates epidermal growth factor receptor signaling in Her-2 negative breast cancer cells.
26362938 2015 Expression and clinical significance of annexin A2 and human epididymis protein 4 in endometrial carcinoma.
26307676 2015 Anxa2 binds to STAT3 and promotes epithelial to mesenchymal transition in breast cancer cells.
26272794 2015 MIEN1, a novel interactor of Annexin A2, promotes tumor cell migration by enhancing AnxA2 cell surface expression.
More...