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Tbio
EDN1
Endothelin-1

Protein Summary
Description
Endothelins are endothelium-derived vasoconstrictor peptides. This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379375
  • ENSP00000368683
  • ENSG00000078401

Symbol
  • ET1
  • QME
  • PPET1
  • ARCND3
  • HDLCQ7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
PubMedID
1
gene perturbation
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15477.05   (req: < 5)
Gene RIFs: 789   (req: <= 3)
Antibodies: 741   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15477.05   (req: >= 5)
Gene RIFs: 789   (req: > 3)
Antibodies: 741   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 100
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0