Property Summary

NCBI Gene PubMed Count 16
PubMed Score 112.86
PubTator Score 29.21

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (3)

Disease Target Count
Prostatic Neoplasms 471
Disease Target Count P-value
adrenocortical carcinoma 1427 6.83209376943592E-9
osteosarcoma 7933 1.07670971504077E-4
ovarian cancer 8492 1.63814000507953E-4
astrocytoma 1493 0.00183319168867245
group 3 medulloblastoma 2254 0.0338508328309034

Expression

  Differential Expression (5)

Disease log2 FC p
osteosarcoma 2.097 0.000
astrocytoma 2.000 0.002
adrenocortical carcinoma -2.252 0.000
group 3 medulloblastoma 1.300 0.034
ovarian cancer 1.600 0.000

Synonym

Accession O96006 Q96BY4
Symbols ALTE
DREF
TRAMP
hDREF

Gene

PDB

2CT5  

  Ortholog (5)

Species Source
Macaque OMA EggNOG Inparanoid
Cow OMA Inparanoid
Platypus OMA Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA EggNOG

Gene RIF (4)

PMID Text
25210186 These findings identify DREF as a novel adenovirus E1A C terminus binding partner and provide evidence supporting a role for DREF in viral replication.
17220279 hDREF is an important transcription factor for cell proliferation which plays roles in cell cycle-dependent regulation of a number of ribosomal protein genes
17209048 self-association of hDREF via the hATC domain is necessary for its nuclear accumulation and DNA binding.
12663651 expression of hDREF/KIAA0785 may have a role in regulation of human genes related to cell proliferation

AA Sequence

MENKSLESSQTDLKLVAHPRAKSKVWKYFGFDTNAEGCILQWKKIYCRICMAQIAYSGNTSNLSYHLEKN      1 - 70
HPEEFCEFVKSNTEQMREAFATAFSKLKPESSQQPGQDALAVKAGHGYDSKKQQELTAAVLGLICEGLYP     71 - 140
ASIVDEPTFKVLLKTADPRYELPSRKYISTKAIPEKYGAVREVILKELAEATWCGISTDMWRSENQNRAY    141 - 210
VTLAAHFLGLGAPNCLSMGSRCLKTFEVPEENTAETITRVLYEVFIEWGISAKVFGATTNYGKDIVKACS    211 - 280
LLDVAVHMPCLGHTFNAGIQQAFQLPKLGALLSRCRKLVEYFQQSAVAMYMLYEKQKQQNVAHCMLVSNR    281 - 350
VSWWGSTLAMLQRLKEQQFVIAGVLVEDSNNHHLMLEASEWATIEGLVELLQPFKQVAEMLSASRYPTIS    351 - 420
MVKPLLHMLLNTTLNIKETDSKELSMAKEVIAKELSKTYQETPEIDMFLNVATFLDPRYKRLPFLSAFER    421 - 490
QQVENRVVEEAKGLLDKVKDGGYRPAEDKIFPVPEEPPVKKLMRTSTPPPASVINNMLAEIFCQTGGVED    491 - 560
QEEWHAQVVEELSNFKSQKVLGLNEDPLKWWSDRLALFPLLPKVLQKYWCVTATRVAPERLFGSAANVVS    561 - 630
AKRNRLAPAHVDEQVFLYENARSGAEAEPEDQDEGEWGLDQEQVFSLGDGVSGGFFGIRDSSFL          631 - 694
//

Text Mined References (19)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
25210186 2014 Adenovirus E1A targets the DREF nuclear factor to regulate virus gene expression, DNA replication, and growth.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23533661 2013 ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions.
21516116 2011 Next-generation sequencing to generate interactome datasets.
21269460 2011 Initial characterization of the human central proteome.
19447967 2009 Shifted Transversal Design smart-pooling for high coverage interactome mapping.
17220279 2007 hDREF regulates cell proliferation and expression of ribosomal protein genes.
17209048 2007 Human DNA replication-related element binding factor (hDREF) self-association via hATC domain is necessary for its nuclear accumulation and DNA binding.
16713569 2006 A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
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