Property Summary

NCBI Gene PubMed Count 26
Grant Count 199
R01 Count 34
Funding $1,424,410,736.64
PubMed Score 990.49
PubTator Score 284.06

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (15)

Synonym

Accession O94900 Q96AV5
Symbols TOX1

Gene

TOX

Gene RIF (13)

PMID Text
26139146 Significant associations between single nucleotide polymorphisms in TOX, CDKN2A/B and type 2 diabetes meillitus.
26125895 The SLC2A9 (rs7660895) and TOX (rs11777927) gene polymorphisms may be associated with formation of intracranial aneurysms, and rs7660895 may be associated with intracranial aneurysms rupture.
25548321 High TOX transcript levels correlate with increased cutaneous T-cell lymphoma.
25216799 TOX may be a specific marker for tumour cells in some types of cutaneous lymphoma.
23415668 SNP rs2726600 is located in a transcription-factor binding site in the 3' region of TOX.
22496870 Compared with TOX4, expression of TOX1, TOX2 and TOX3 in normal lung was 25, 44, and 88%lower, respectively, supporting the premise that reduced promoter activity confers increased susceptibility to methylation during lung carcinogenesis.
21126536 results suggest that TOX is required for IL-15-mediated natural killer (NK) cell differentiation and affected expression of T-bet that plays critical roles in NK differentiation and maturation
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19023099 Observational study of gene-disease association. (HuGE Navigator)
17975119 Observational study of gene-disease association. (HuGE Navigator)
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AA Sequence

MDVRFYPPPAQPAAAPDAPCLGPSPCLDPYYCNKFDGENMYMSMTEPSQDYVPASQSYPGPSLESEDFNI      1 - 70
PPITPPSLPDHSLVHLNEVESGYHSLCHPMNHNGLLPFHPQNMDLPEITVSNMLGQDGTLLSNSISVMPD     71 - 140
IRNPEGTQYSSHPQMAAMRPRGQPADIRQQPGMMPHGQLTTINQSQLSAQLGLNMGGSNVPHNSPSPPGS    141 - 210
KSATPSPSSSVHEDEGDDTSKINGGEKRPASDMGKKPKTPKKKKKKDPNEPQKPVSAYALFFRDTQAAIK    211 - 280
GQNPNATFGEVSKIVASMWDGLGEEQKQVYKKKTEAAKKEYLKQLAAYRASLVSKSYSEPVDVKTSQPPQ    281 - 350
LINSKPSVFHGPSQAHSALYLSSHYHQQPGMNPHLTAMHPSLPRNIAPKPNNQMPVTVSIANMAVSPPPP    351 - 420
LQISPPLHQHLNMQQHQPLTMQQPLGNQLPMQVQSALHSPTMQQGFTLQPDYQTIINPTSTAAQVVTQAM    421 - 490
EYVRSGCRNPPPQPVDWNNDYCSSGGMQRDKALYLT                                      491 - 526
//

Text Mined References (27)

PMID Year Title
26139146 2015 TOX and CDKN2A/B Gene Polymorphisms Are Associated with Type 2 Diabetes in Han Chinese.
26125895 2015 Intracranial aneurysm risk factor genes: relationship with intracranial aneurysm risk in a Chinese Han population.
25548321 2015 Evidence of an oncogenic role of aberrant TOX activation in cutaneous T-cell lymphoma.
25367360 2015 Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium.
25233373 2014 Genome-wide meta-analysis of myopia and hyperopia provides evidence for replication of 11 loci.
25216799 2014 TOX expression in different subtypes of cutaneous lymphoma.
23415668 2013 Age-dependent association between pulmonary tuberculosis and common TOX variants in the 8q12-13 linkage region.
23396134 2013 Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.
22589738 2012 Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
22496870 2012 Differential epigenetic regulation of TOX subfamily high mobility group box genes in lung and breast cancers.
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