Property Summary

NCBI Gene PubMed Count 19
Grant Count 5
R01 Count 2
Funding $1,839,935
PubMed Score 107.75
PubTator Score 57.71

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (2)

Disease log2 FC p
lung carcinoma 4.000 0.000
psoriasis -1.100 0.006

Synonym

Accession O75829 Q5TAM4 Q8TAY6 Q9UM18
Symbols CHM1
CHM-I
LECT1
BRICD3
MYETS1

Gene

Gene RIF (11)

PMID Text
26165347 Data suggest ChM1 as potential tumor suppressor in gastric cancer and useful biomarker for the treatment and prognosis. Its expression was downregulated in cancer tissue, and correlated with advanced stages, lymph node metastasis, and poorer prognosis.
24710035 intact 20-25 kDa ChM-I is stored as a component of extracellular matrix in the avascular cartilage zones, but it is inactivated by a single N-terminal proteolytic cleavage in the hypertrophic zone of growth-plate cartilage
23143879 the inner meniscus contained larger amounts of ChM-I, and that the inner meniscus-derived ChM-I inhibited endothelial cell proliferation.
22041680 Degenerative intervertebral disc cells express ChM-I. Administration of bFGF down-regulates the expression of ChM-I. Expression is correlated with the degree of degeneration.
20663886 Inhibition of YY1 in combination with forced expression of p300 and Sp3 restored the expression of ChM-I in cells with a hypomethylated promoter region, but not in cells with hypermethylation.
20026108 Data suggest that chondromodulin-I impairs the VEGF-A-stimulated motility of endothelial cells by destabilizing lamellipodial extensions.
18077449 new hypoxia-inducible and SOX9-regulated genes, Gdf10 and Chm-I. In addition, Mig6 and InhbA were induced by hypoxia, predominantly via HIF-2alpha
17980151 Cell-specific epigenetic regulation of ChM-I gene expression
16980969 chondromodulin-I has a pivotal role in maintaining valvular normal function by preventing angiogenesis that may lead to valvular heart diseases
16142856 Observational study of gene-disease association. (HuGE Navigator)
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AA Sequence

MTENSDKVPIALVGPDDVEFCSPPAYATLTVKPSSPARLLKVGAVVLISGAVLLLFGAIGAFYFWKGSDS      1 - 70
HIYNVHYTMSINGKLQDGSMEIDAGNNLETFKMGSGAEEAIAVNDFQNGITGIRFAGGEKCYIKAQVKAR     71 - 140
IPEVGAVTKQSISSKLEGKIMPVKYEENSLIWVAVDQPVKDNSFLSSKVLELCGDLPIFWLKPTYPKEIQ    141 - 210
RERREVVRKIVPTTTKRPHSGPRSNPGAGRLNNETRPSVQEDSQAFNPDNPYHQQEGESMTFDPRLDHEG    211 - 280
ICCIECRRSYTHCQKICEPLGGYYPWPYNYQGCRSACRVIMPCSWWVARILGMV                    281 - 334
//

Text Mined References (21)

PMID Year Title
26165347 2015 Chondromodulin-1 functions as a tumor suppressor in gastric adenocarcinoma.
24710035 2014 The N-terminal cleavage of chondromodulin-I in growth-plate cartilage at the hypertrophic and calcified zones during bone development.
23143879 2013 Chondromodulin-I derived from the inner meniscus prevents endothelial cell proliferation.
22041680 2011 [Expression of chondromodulin-1 in the adult degenerative intervertebral disc].
20663886 2010 Histone modifiers, YY1 and p300, regulate the expression of cartilage-specific gene, chondromodulin-I, in mesenchymal stem cells.
20026108 2010 Impairment of VEGF-A-stimulated lamellipodial extensions and motility of vascular endothelial cells by chondromodulin-I, a cartilage-derived angiogenesis inhibitor.
18077449 2008 Hypoxia promotes the differentiated human articular chondrocyte phenotype through SOX9-dependent and -independent pathways.
17980151 2008 Cell-specific epigenetic regulation of ChM-I gene expression: crosstalk between DNA methylation and histone acetylation.
16980969 2006 Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis.
16142856 2005 Association of chondromodulin-II Val58Ile polymorphism with radiographic joint destruction in rheumatoid arthritis.
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