| Tbio | Nucleoside diphosphate kinase 6 |
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis.
Nucleoside diphosphate (NDP) kinases (EC 2.7.4.6), such as NME6, are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates (Mehus et al., 1999 [PubMed 10453732]).[supplied by OMIM, Jul 2010]
Nucleoside diphosphate (NDP) kinases (EC 2.7.4.6), such as NME6, are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates (Mehus et al., 1999 [PubMed 10453732]).[supplied by OMIM, Jul 2010]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ependymoma | 4679 | 7.4e-14 |
| pediatric high grade glioma | 1064 | 4.2e-08 |
| glioblastoma | 5792 | 4.5e-05 |
| primitive neuroectodermal tumor | 3035 | 1.5e-04 |
| group 3 medulloblastoma | 4104 | 1.9e-04 |
| Pick disease | 1894 | 2.9e-04 |
| Disease | log2 FC | p |
|---|---|---|
| ependymoma | 1.300 | 7.4e-14 |
| glioblastoma | 1.100 | 4.5e-05 |
| group 3 medulloblastoma | 1.300 | 1.9e-04 |
| pediatric high grade glioma | 1.200 | 4.2e-08 |
| Pick disease | 1.100 | 2.9e-04 |
| primitive neuroectodermal tumor | 1.200 | 1.5e-04 |
