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Tbio Nucleoside diphosphate kinase 6

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis.

Nucleoside diphosphate (NDP) kinases (EC 2.7.4.6), such as NME6, are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates (Mehus et al., 1999 [PubMed 10453732]).[supplied by OMIM, Jul 2010]

 Comments

Property Summary

NCBI Gene PubMed Count 9
PubMed Score 6.16
PubTator Score 5.90

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Relevance (6)

Disease Z-score Confidence
Pick disease 1,893
glioblastoma 5,572
group 3 medulloblastoma 2,254
pediatric high grade glioma 2,712
posterior fossa group A ependymoma 1,511
primitive neuroectodermal tumor 3,031

Expression

  Differential Expression (6)

Disease log2 FC p
posterior fossa group A ependymoma 1.400 0.000
glioblastoma 1.100 0.000
primitive neuroectodermal tumor 1.200 0.000
pediatric high grade glioma 1.200 0.000
group 3 medulloblastoma 1.300 0.000
Pick disease 1.100 0.000

Synonym

Accession O75414 B4DGW7 B4DM99 Q53HM5 Q96E73 Q9BQ63 NDK 6
Symbols NDK 6
NM23-H6
IPIA-ALPHA

Gene

NME6

PANTHER Protein Class (3)

 GO Function (3)

 GO Component (1)

 GO Process (6)

 Compartment GO Term (12)

 IMPC Term (6)

 MGI Term (2)

Pathway (55)

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 UniProt Keyword (11)

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Gene RIF (2)

PMID Text
25496667 Genome-wide shRNA screening identifies NME6, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells
20877624 Observational study of gene-disease association. (HuGE Navigator)

AA Sequence 

MASILRSPQALQLTLALIKPDAVAHPLILEAVHQQILSNKFLIVRMRELLWRKEDCQRFYREHEGRFFYQ      1 - 70
RLVEFMASGPIRAYILAHKDAIQLWRTLMGPTRVFRARHVAPDSIRGSFGLTDTRNTTHGSDSVVSASRE     71 - 140
IAAFFPDFSEQRWYEEEEPQLRCGPVCYSPEGGVHYVAGTGGLGPA                            141 - 186
//

Text Mined References (13)

PMID Year Title
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
21269460 2011 Initial characterization of the human central proteome.
20877624 2010 Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
19852809 2009 Nme protein family evolutionary history, a vertebrate perspective.
16641997 2006 The DNA sequence, annotation and analysis of human chromosome 3.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15146197 2004 Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
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