Tbio | Nucleoside diphosphate kinase 6 |
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis.
Nucleoside diphosphate (NDP) kinases (EC 2.7.4.6), such as NME6, are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates (Mehus et al., 1999 [PubMed 10453732]).[supplied by OMIM, Jul 2010]
Nucleoside diphosphate (NDP) kinases (EC 2.7.4.6), such as NME6, are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates (Mehus et al., 1999 [PubMed 10453732]).[supplied by OMIM, Jul 2010]
Comments
Disease | Target Count | P-value |
---|---|---|
posterior fossa group A ependymoma | 1511 | 2.56559633505433E-12 |
pediatric high grade glioma | 2712 | 4.23755828931457E-8 |
glioblastoma | 5572 | 4.53605358078144E-5 |
primitive neuroectodermal tumor | 3031 | 1.50381118661591E-4 |
group 3 medulloblastoma | 2254 | 1.94748776190964E-4 |
Pick disease | 1893 | 2.9038320971621E-4 |
Disease | log2 FC | p |
---|---|---|
posterior fossa group A ependymoma | 1.400 | 0.000 |
glioblastoma | 1.100 | 0.000 |
primitive neuroectodermal tumor | 1.200 | 0.000 |
pediatric high grade glioma | 1.200 | 0.000 |
group 3 medulloblastoma | 1.300 | 0.000 |
Pick disease | 1.100 | 0.000 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Macaque | OMA EggNOG Inparanoid |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Cow | OMA EggNOG Inparanoid |
Opossum | OMA EggNOG Inparanoid |
Anole lizard | OMA EggNOG Inparanoid |
Xenopus | OMA EggNOG Inparanoid |
Fruitfly | EggNOG Inparanoid |
PMID | Year | Title |
---|---|---|
25944712 | 2015 | N-terminome analysis of the human mitochondrial proteome. |
21269460 | 2011 | Initial characterization of the human central proteome. |
20877624 | 2010 | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. |
19852809 | 2009 | Nme protein family evolutionary history, a vertebrate perspective. |
16641997 | 2006 | The DNA sequence, annotation and analysis of human chromosome 3. |
16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |
15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
15146197 | 2004 | Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |
14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. |
12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
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