Tbio MPZL2 Myelin protein zero-like protein 2

Protein Summary

Description

Mediates homophilic cell-cell adhesion. Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain; a putative serine phosphorylation site for casein kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O60487
• A8K2R1

Gene Name

• MPZL2

Ensembl ID

• ENST00000278937
• ENSP00000278937
• ENSG00000149573
• ENST00000438295
• ENSP00000408362

Symbol

• EVA
• EVA1
• EVA
• EVA1
• DFNB111

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.99
transcription factor perturbation	0.99
PubMedID	0.74
protein domain	0.73
kinase perturbation	0.71

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Voltage-gated Ion Channel / Voltage-gated Sodium Channel / Myelin Protein Zero-like Protein 2

Protein / Transporter / Ion Channel / Sodium Channel / Voltage-gated Sodium Channel / Myelin Protein Zero-like Protein 2

Protein / Cell Adhesion Molecule / Myelin Protein Zero-like Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.12   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 229   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.12   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 229   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0