Property Summary

NCBI Gene PubMed Count 10
Grant Count 28
R01 Count 4
Funding $16,389,862.56
PubMed Score 10.24
PubTator Score 23.22

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (20)

Disease log2 FC p
Rheumatoid Arthritis -1.200 0.007
hepatocellular carcinoma 1.100 0.001
esophageal adenocarcinoma -1.900 0.029
psoriasis 2.600 0.000
cutaneous lupus erythematosus 2.200 0.002
osteosarcoma -1.194 0.000
Atopic dermatitis 1.500 0.001
intraductal papillary-mucinous adenoma (... 2.000 0.004
intraductal papillary-mucinous neoplasm ... 2.400 0.007
pancreatic cancer 1.500 0.000
fibroadenoma 1.200 0.039
interstitial cystitis -1.900 0.000
lung adenocarcinoma 1.325 0.004
Endometriosis -1.331 0.020
lung carcinoma -2.900 0.000
spina bifida -1.561 0.030
Breast cancer -2.000 0.000
ductal carcinoma in situ 1.600 0.008
ovarian cancer 2.900 0.000
pituitary cancer -1.800 0.000

Gene RIF (3)

PMID Text
26930581 CLCA2 links junctional adhesion molecule EVA1, to cytosolic signaling proteins that modulate proliferation and differentiation.
26677976 Findings highlight Eva1 as a novel regulator of GIC function and also provide new mechanistic insight into the role of noncanonical NF-kappaB activation in GIC.
21440040 EVA is expressed in human choroid plexus epithelial cells and CD4 T lymphocytes and regulates CD4+ T lymphocyte adhesion to human choroid plexus epithelial cells in vitro. These data suggest a novel mechanism to regulate CNS immune surveillance.

AA Sequence

MYGKSSTRAVLLLLGIQLTALWPIAAVEIYTSRVLEAVNGTDARLKCTFSSFAPVGDALTVTWNFRPLDG      1 - 70
GPEQFVFYYHIDPFQPMSGRFKDRVSWDGNPERYDASILLWKLQFDDNGTYTCQVKNPPDVDGVIGEIRL     71 - 140
SVVHTVRFSEIHFLALAIGSACALMIIIVIVVVLFQHYRKKRWAERAHKVVEIKSKEEERLNQEKKVSVY    141 - 210
LEDTD                                                                     211 - 215
//

Text Mined References (12)

PMID Year Title
26930581 2016 CLCA2 Interactor EVA1 Is Required for Mammary Epithelial Cell Differentiation.
26677976 2016 Eva1 Maintains the Stem-like Character of Glioblastoma-Initiating Cells by Activating the Noncanonical NF-?B Signaling Pathway.
21982860 2012 A secreted protein microarray platform for extracellular protein interaction discovery.
21440040 2011 Characterization of epithelial V-like antigen in human choroid plexus epithelial cells: potential role in CNS immune surveillance.
19159218 2009 Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
17207965 2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12975309 2003 The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
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