| Tbio | LanC-like protein 1 |
May play a role in EPS8 signaling. Binds glutathione.
This gene encodes a loosely associated peripheral membrane protein related to the LanC family of bacterial membrane-associated proteins involved in the biosynthesis of antimicrobial peptides. This protein may play a role as a peptide-modifying enzyme component in eukaryotic cells. Previously considered a member of the G-protein-coupled receptor superfamily, this protein is now in the LanC family. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]
This gene encodes a loosely associated peripheral membrane protein related to the LanC family of bacterial membrane-associated proteins involved in the biosynthesis of antimicrobial peptides. This protein may play a role as a peptide-modifying enzyme component in eukaryotic cells. Previously considered a member of the G-protein-coupled receptor superfamily, this protein is now in the LanC family. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ependymoma | 4679 | 2.4e-11 |
| atypical teratoid / rhabdoid tumor | 5112 | 4.7e-08 |
| ovarian cancer | 8520 | 4.8e-08 |
| malignant mesothelioma | 3232 | 7.1e-06 |
| glioblastoma | 5792 | 2.3e-05 |
| medulloblastoma, large-cell | 6241 | 4.2e-05 |
| Pick disease | 1894 | 4.5e-05 |
| adult high grade glioma | 3801 | 1.6e-04 |
| osteosarcoma | 7950 | 2.8e-04 |
| lung cancer | 4740 | 3.2e-04 |
| group 3 medulloblastoma | 4104 | 2.8e-03 |
| subependymal giant cell astrocytoma | 2287 | 5.9e-03 |
| progressive supranuclear palsy | 676 | 1.4e-02 |
| Breast cancer | 3578 | 2.4e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.400 | 1.6e-04 |
| atypical teratoid / rhabdoid tumor | -1.900 | 4.7e-08 |
| Breast cancer | 3.300 | 2.4e-02 |
| ependymoma | -1.600 | 2.4e-11 |
| glioblastoma | -1.100 | 2.3e-05 |
| group 3 medulloblastoma | -1.300 | 2.8e-03 |
| lung cancer | 1.300 | 3.2e-04 |
| malignant mesothelioma | -1.400 | 7.1e-06 |
| medulloblastoma, large-cell | -1.200 | 4.2e-05 |
| osteosarcoma | 1.406 | 2.8e-04 |
| ovarian cancer | -2.500 | 4.8e-08 |
| Pick disease | -1.700 | 4.5e-05 |
| progressive supranuclear palsy | -1.600 | 1.4e-02 |
| subependymal giant cell astrocytoma | -2.163 | 5.9e-03 |
MAQRAFPNPYADYNKSLAEGYFDAAGRLTPEFSQRLTNKIRELLQQMERGLKSADPRDGTGYTGWAGIAV 1 - 70 LYLHLYDVFGDPAYLQLAHGYVKQSLNCLTKRSITFLCGDAGPLAVAAVLYHKMNNEKQAEDCITRLIHL 71 - 140 NKIDPHAPNEMLYGRIGYIYALLFVNKNFGVEKIPQSHIQQICETILTSGENLARKRNFTAKSPLMYEWY 141 - 210 QEYYVGAAHGLAGIYYYLMQPSLQVSQGKLHSLVKPSVDYVCQLKFPSGNYPPCIGDNRDLLVHWCHGAP 211 - 280 GVIYMLIQAYKVFREEKYLCDAYQCADVIWQYGLLKKGYGLCHGSAGNAYAFLTLYNLTQDMKYLYRACK 281 - 350 FAEWCLEYGEHGCRTPDTPFSLFEGMAGTIYFLADLLVPTKARFPAFEL 351 - 399 //
