Protein Summary
May be involved in transcriptional regulation. Zinc finger proteins (ZNFs), such as ZNF208, bind DNA and, through this binding, regulate gene transcription. Most ZNFs contain conserved C2H2 motifs and are classified as Kruppel-type zinc fingers. A conserved protein motif, termed the Kruppel-associated box (KRAB) domain, mediates protein-protein interactions (Eichler et al., 1998 [PubMed 9724325]). See ZNF91 (MIM 603971) for further information on ZNFs.[supplied by OMIM, Aug 2009]
- ENST00000397126
- ENSP00000380315
- ENSG00000160321
- ZNF91L
- PMIDP
- ZNF95
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
cell line | 0.58 | ||
protein domain | 0.58 | ||
tissue sample | 0.47 | ||
tissue | 0.44 | ||
cell type or tissue | 0.42 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.7 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 3 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.7 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 3 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0