Property Summary

NCBI Gene PubMed Count 9
PubMed Score 11.89
PubTator Score 8.60

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (9)

Disease log2 FC p
hepatocellular carcinoma 1.400 0.000
osteosarcoma -2.136 0.000
ependymoma 1.400 0.000
glioblastoma 1.300 0.000
atypical teratoid/rhabdoid tumor 1.500 0.000
ulcerative colitis -1.312 0.029
pediatric high grade glioma 1.400 0.000
pilocytic astrocytoma 1.200 0.000
ovarian cancer -1.600 0.000

Synonym

Accession O14772 A6NMH3 B4DRX2 B4E2Y7 E9PNQ2 Q8N5J7
Symbols GFPP

Gene

Gene RIF (3)

PMID Text
16582493 A complete native data set has been collected as a first step in determining the three-dimensional structure of this enzyme.
16185085 identified five amino acid residues that are critical for catalysis.
16086588 the nature of the purine base is the major determinant in substrate specificity, followed by the nature of the hexose-1-P, and finally by the ribose moiety. Binding is enthalpy-driven and does not involve proton transfer

AA Sequence

MAAARDPPEVSLREATQRKLRRFSELRGKLVARGEFWDIVAITAADEKQELAYNQQLSEKLKRKELPLGV      1 - 70
QYHVFVDPAGAKIGNGGSTLCALQCLEKLYGDKWNSFTILLIHSGGYSQRLPNASALGKIFTALPLGNPI     71 - 140
YQMLELKLAMYIDFPLNMNPGILVTCADDIELYSIGEFEFIRFDKPGFTALAHPSSLTIGTTHGVFVLDP    141 - 210
FDDLKHRDLEYRSCHRFLHKPSIEKMYQFNAVCRPGNFCQQDFAGGDIADLKLDSDYVYTDSLFYMDHKS    211 - 280
AKMLLAFYEKIGTLSCEIDAYGDFLQALGPGATVEYTRNTSNVIKEESELVEMRQRIFHLLKGTSLNVVV    281 - 350
LNNSKFYHIGTTEEYLFYFTSDNSLKSELGLQSITFSIFPDIPECSGKTSCIIQSILDSRCSVAPGSVVE    351 - 420
YSRLGPDVSVGENCIISGSYILTKAALPAHSFVCSLSLKMNRCLKYATMAFGVQDNLKKSVKTLSDIKLL    421 - 490
QFFGVCFLSCLDVWNLKVTEELFSGNKTCLSLWTARIFPVCSSLSDSVITSLKMLNAVKNKSAFSLNSYK    491 - 560
LLSIEEMLIYKDVEDMITYREQIFLEISLKSSLM                                        561 - 594
//

Text Mined References (11)

PMID Year Title
26871637 2016 Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
16710414 2006 The DNA sequence and biological annotation of human chromosome 1.
16582493 2006 Purification, crystallization and preliminary X-ray characterization of the human GTP fucose pyrophosphorylase.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
16185085 2005 Identification of catalytic amino acids in the human GTP fucose pyrophosphorylase active site.
16086588 2005 Substrate discrimination by the human GTP fucose pyrophosphorylase.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
9804772 1998 GDP-L-fucose pyrophosphorylase. Purification, cDNA cloning, and properties of the enzyme.
More...