Property Summary

NCBI Gene PubMed Count 11
PubMed Score 95.08
PubTator Score 31.10

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (3)

Disease Target Count
Down syndrome 548
Muscle Weakness 92
Disease Target Count P-value
ovarian cancer 8492 9.60231127941456E-5
pancreatic carcinoma 567 0.0010473525716831
pancreatic cancer 2300 0.00104735257168311
osteosarcoma 7933 0.00177719736347101
cystic fibrosis and chronic rhinosinusitis 213 0.0416490406386867
chronic rhinosinusitis 512 0.0435464430967759

Expression

  Differential Expression (6)

Disease log2 FC p
pancreatic cancer 1.600 0.001
osteosarcoma 1.279 0.002
pancreatic carcinoma 1.600 0.001
ovarian cancer -1.900 0.000
chronic rhinosinusitis -1.249 0.044
cystic fibrosis and chronic rhinosinusit... -1.081 0.042

Synonym

Accession O00258 A8KAP8 A8MQ44 D3DSH9 O60740
Symbols CHD5
GET1

Gene

WRB

  Ortholog (11)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG Inparanoid
Chicken OMA Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid

Pathway (1)

Gene RIF (4)

PMID Text
27100087 WRB gene contains a maternally imprinted differentially methylated region (DMR). The maternally inherited 5mCpG imprints at the WRB DMR are uncoupled from the parental allele expression of WRB and ten neighboring genes in twelve biosamples (brain, blood, fallopian tube, fetal large and small intestine, hESCs, large airway epithelial cells, thyroid, muscle, epidermal keratinocytes, ovary, skin, and testis).
23041287 Results indicate calcium-modulating cyclophilin ligand (CAML) and WRB as components of the TRC40 receptor complex and a crucial mechanism for driving ER membrane insertion of TA proteins in mammalian cells.
21444755 The coiled-coil domain of WRB is the binding site for TRC40/Asna1.
20200978 Observational study of gene-disease association. (HuGE Navigator)

AA Sequence

MSSAAADHWAWLLVLSFVFGCNVLRILLPSFSSFMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFA      1 - 70
RYARLERKINKMTDKLKTHVKARTAQLAKIKWVISVAFYVLQAALMISLIWKYYSVPVAVVPSKWITPLD     71 - 140
RLVAFPTRVAGGVGITCWILVCNKVVAIVLHPFS                                        141 - 174
//

Text Mined References (12)

PMID Year Title
27100087 2016 Trisomy 21 Alters DNA Methylation in Parent-of-Origin-Dependent and -Independent Manners.
23041287 2012 Molecular machinery for insertion of tail-anchored membrane proteins into the endoplasmic reticulum membrane in mammalian cells.
21444755 2011 WRB is the receptor for TRC40/Asna1-mediated insertion of tail-anchored proteins into the ER membrane.
20200978 2010 Replication of previous genome-wide association studies of bone mineral density in premenopausal American women.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12189208 2002 Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator.
10830953 2000 The DNA sequence of human chromosome 21.
More...