| Tdark | Nucleoporin p58/p45 |
Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.
This gene encodes a member of the nucleoporin family that shares 87% sequence identity with rat nucleoporin p58. The protein is localized to the nuclear rim and is a component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
This gene encodes a member of the nucleoporin family that shares 87% sequence identity with rat nucleoporin p58. The protein is localized to the nuclear rim and is a component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 2.4e-17 |
| ovarian cancer | 8520 | 1.9e-15 |
| posterior fossa group B ependymoma | 416 | 1.7e-06 |
| medulloblastoma, large-cell | 6241 | 1.1e-05 |
| osteosarcoma | 7950 | 3.9e-05 |
| Astrocytoma, Pilocytic | 3081 | 2.5e-04 |
| tuberculosis | 2010 | 2.7e-04 |
| Pick disease | 1894 | 3.5e-04 |
| nasopharyngeal carcinoma | 1058 | 4.3e-04 |
| hepatocellular carcinoma | 547 | 8.1e-04 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 2.0e-03 |
| group 4 medulloblastoma | 1855 | 2.1e-03 |
| atypical teratoid / rhabdoid tumor | 5112 | 2.8e-03 |
| glioblastoma | 5792 | 2.9e-03 |
| Rheumatoid arthritis | 1191 | 4.9e-03 |
| astrocytic glioma | 2597 | 6.9e-03 |
| oligodendroglioma | 2850 | 1.2e-02 |
| primitive neuroectodermal tumor | 3035 | 1.2e-02 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 1.6e-02 |
| colon cancer | 1478 | 2.3e-02 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 2.4e-02 |
| spina bifida | 1074 | 3.1e-02 |
| adult high grade glioma | 3801 | 3.6e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | 1.100 | 3.6e-02 |
| astrocytic glioma | -1.500 | 6.9e-03 |
| Astrocytoma, Pilocytic | -1.300 | 2.5e-04 |
| atypical teratoid / rhabdoid tumor | 1.700 | 2.8e-03 |
| colon cancer | 2.300 | 2.3e-02 |
| glioblastoma | 1.400 | 2.9e-03 |
| group 4 medulloblastoma | 1.200 | 2.1e-03 |
| hepatocellular carcinoma | -1.900 | 8.1e-04 |
| intraductal papillary-mucinous adenoma (... | 1.300 | 2.0e-03 |
| intraductal papillary-mucinous neoplasm ... | 1.500 | 2.4e-02 |
| medulloblastoma, large-cell | 2.500 | 1.1e-05 |
| nasopharyngeal carcinoma | 1.200 | 4.3e-04 |
| non-small cell lung cancer | -1.712 | 2.4e-17 |
| oligodendroglioma | -1.800 | 1.2e-02 |
| osteosarcoma | -2.158 | 3.9e-05 |
| ovarian cancer | -2.100 | 1.9e-15 |
| pancreatic ductal adenocarcinoma liver m... | 1.311 | 1.6e-02 |
| Pick disease | 1.400 | 3.5e-04 |
| posterior fossa group B ependymoma | -1.500 | 1.7e-06 |
| primitive neuroectodermal tumor | 1.300 | 1.2e-02 |
| Rheumatoid arthritis | 2.200 | 4.9e-03 |
| spina bifida | -2.415 | 3.1e-02 |
| tuberculosis | -1.300 | 2.7e-04 |
MSTGFSFGSGTLGSTTVAAGGTSTGGVFSFGTGASSNPSVGLNFGNLGSTSTPATTSAPSSGFGTGLFGS 1 - 70 KPATGFTLGGTNTGIATTITTGLTLGTPATTSAATTGFSLGFNKPAASATPFALPITSTSASGLTLSSAL 71 - 140 TSTPAASTGFTLNNLGGTTATTTTASTGLSLGGALAGLGGSLFQSTNTGTSGLGQNALGLTLGTTAATST 141 - 210 AGNEGLGGIDFSSSSDKKSDKTGTRPEDSKALKDENLPPVICQDVENLQKFVKEQKQVQEEISRMSSKAM 211 - 280 LKVQEDIKALKQLLSLAANGIQRNTLNIDKLKIETAQELKNAEIALRTQKTPPGLQHEYAAPADYFRILV 281 - 350 QQFEVQLQQYRQQIEELENHLATQANNSHITPQDLSMAMQKIYQTFVALAAQLQSIHENVKVLKEQYLGY 351 - 420 RKMFLGDAVDVFETRRAEAKKWQNTPRVTTGPTPFSTMPNAAAVAMAATLTQQQQPATGPQPSLGVSFGT 421 - 490 PFGSGIGTGLQSSGLGSSNLGGFGTSSGFGCSTTGASTFGFGTTNKPSGSLSAGFGSSSTSGFNFSNPGI 491 - 560 TASAGLTFGVSNPASAGFGTGGQLLQLKKPPAGNKRGKR 561 - 599 //
