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Tdark Nucleoporin p58/p45

Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.

This gene encodes a member of the nucleoporin family that shares 87% sequence identity with rat nucleoporin p58. The protein is localized to the nuclear rim and is a component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

 Comments

Property Summary

NCBI Gene PubMed Count 16
PubMed Score 5.23
PubTator Score 3.53

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (1)

Expression

  Differential Expression (23)

Disease log2 FC p
Rheumatoid Arthritis 2.200 4.9e-03
hepatocellular carcinoma -1.900 8.1e-04
astrocytic glioma 1.600 1.7e-02
oligodendroglioma -1.800 1.2e-02
osteosarcoma -2.158 3.9e-05
atypical teratoid / rhabdoid tumor 1.700 2.8e-03
glioblastoma 1.400 2.9e-03
medulloblastoma 1.300 4.1e-03
medulloblastoma, large-cell 2.500 1.1e-05
primitive neuroectodermal tumor 1.600 1.3e-04
pancreatic ductal adenocarcinoma liver m... 1.311 1.6e-02
tuberculosis and treatment for 3 months -1.600 5.1e-07
non-small cell lung cancer -1.712 2.4e-17
intraductal papillary-mucinous adenoma (... 1.300 2.0e-03
intraductal papillary-mucinous neoplasm ... 1.500 2.4e-02
colon cancer 2.300 2.3e-02
pediatric high grade glioma 1.200 2.8e-03
pilocytic astrocytoma -1.200 2.0e-04
posterior fossa group B ependymoma -1.500 1.7e-06
nasopharyngeal carcinoma 1.200 4.3e-04
spina bifida -2.415 3.1e-02
Pick disease 1.400 3.5e-04
ovarian cancer -2.100 1.9e-15

Synonym

Accession Q9BVL2 A6NI12 B4DZJ1 O43160 Q5JRG2 Q5JRG5
Symbols NUP45
NUPL1
PRO2463

Gene

NUP58

PDB

5IJN   5IJO   4JO7   4JO9   4JQ5  

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (16)

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 GO Function (2)

 GO Component (3)

 GO Process (15)

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 Compartment GO Term (25)

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 HCA RNA Cell Line (56)

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Pathway (64)

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Protein-protein Interaction (69)

POM121C   DDX39A   IGF2BP3   XPO1   IPO8   NUPL2   ZC3H11A   PSIP1   SLU7   NPM1   HSPA1B   HSPA1B   HMGA1   GCK   NUP98   HIST2H4A   HIST1H3F   H3F3B   HNRNPD   RNPS1   CTU2   PAN2   HIKESHI   PAN3   NUP188   THOC7   HIST2H3D   TRMT11   CTU1   ALYREF   THOC6   SRRM1   TRMT44   NUP93   NUP35   THOC2   NSUN6   NUP210   U2AF1L4   NUP205   MAGOHB   ALKBH8   SEH1L   THOC1   POM121   THOC3   URM1   NDC1   NUP85   UPF3B   PAIP1   TRIT1   QTRT2   THG1L   DUS2   IGF2BP1   SAE1   UBA2   TRMT112   AGO2   IGF2BP2   FBXO28   RNF40   GOPC   NUP62   NUP62CL   EEA1   OSBPL6   MIB2  

Gene RIF (1)

PMID Text
7531196 The human gene NUPL1 shares 87% sequence identity with rat nucleoporin p58.

AA Sequence 

MSTGFSFGSGTLGSTTVAAGGTSTGGVFSFGTGASSNPSVGLNFGNLGSTSTPATTSAPSSGFGTGLFGS      1 - 70
KPATGFTLGGTNTGIATTITTGLTLGTPATTSAATTGFSLGFNKPAASATPFALPITSTSASGLTLSSAL     71 - 140
TSTPAASTGFTLNNLGGTTATTTTASTGLSLGGALAGLGGSLFQSTNTGTSGLGQNALGLTLGTTAATST    141 - 210
AGNEGLGGIDFSSSSDKKSDKTGTRPEDSKALKDENLPPVICQDVENLQKFVKEQKQVQEEISRMSSKAM    211 - 280
LKVQEDIKALKQLLSLAANGIQRNTLNIDKLKIETAQELKNAEIALRTQKTPPGLQHEYAAPADYFRILV    281 - 350
QQFEVQLQQYRQQIEELENHLATQANNSHITPQDLSMAMQKIYQTFVALAAQLQSIHENVKVLKEQYLGY    351 - 420
RKMFLGDAVDVFETRRAEAKKWQNTPRVTTGPTPFSTMPNAAAVAMAATLTQQQQPATGPQPSLGVSFGT    421 - 490
PFGSGIGTGLQSSGLGSSNLGGFGTSSGFGCSTTGASTFGFGTTNKPSGSLSAGFGSSSTSGFNFSNPGI    491 - 560
TASAGLTFGVSNPASAGFGTGGQLLQLKKPPAGNKRGKR                                   561 - 599
//

Text Mined References (21)

PMID Year Title
27107012 2016 Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
26496610 2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
25416956 2014 A proteome-scale map of the human interactome network.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23275563 2013 Development and application of a DNA microarray-based yeast two-hybrid system.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
21516116 2011 Next-generation sequencing to generate interactome datasets.
21269460 2011 Initial characterization of the human central proteome.
20068231 2010 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
17500595 2007 Huntingtin interacting proteins are genetic modifiers of neurodegeneration.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15342556 2004 Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.
15057823 2004 The DNA sequence and analysis of human chromosome 13.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12228227 2002 Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1.
11266456 2001 Gradient of increasing affinity of importin beta for nucleoporins along the pathway of nuclear import.
10601273 1999 Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase.
9455477 1997 Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.
8889548 1996 Normalization and subtraction: two approaches to facilitate gene discovery.
7531196 1995 Macromolecular interactions in the nucleoporin p62 complex of rat nuclear pores: binding of nucleoporin p54 to the rod domain of p62.