| Tbio | 5'(3')-deoxyribonucleotidase, cytosolic type |
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.
This gene encodes a nucleotidase that catalyzes the dephosphorylation of the 5' deoxyribonucleotides (dNTP) and 2'(3')-dNTP and ribonucleotides, but not 5' ribonucleotides. Of the different forms of nucleotidases characterized, this enzyme is unique in its preference for 5'-dNTP. It may be one of the enzymes involved in regulating the size of dNTP pools in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]
This gene encodes a nucleotidase that catalyzes the dephosphorylation of the 5' deoxyribonucleotides (dNTP) and 2'(3')-dNTP and ribonucleotides, but not 5' ribonucleotides. Of the different forms of nucleotidases characterized, this enzyme is unique in its preference for 5'-dNTP. It may be one of the enzymes involved in regulating the size of dNTP pools in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Colorectal Neoplasms | 243 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| group 3 medulloblastoma | 4104 | 7.0e-05 |
| primitive neuroectodermal tumor | 3035 | 1.3e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Autoimmune lymphoproliferative syndrome | 11 | 4.271 | 2.1 |
| coronin-1A deficiency | 3 | 4.182 | 2.1 |
| Lupus erythematosus | 57 | 3.985 | 2.0 |
| Lymphoproliferative syndrome | 58 | 3.616 | 1.8 |
| Coccidioidomycosis | 8 | 3.418 | 1.7 |
| Connective tissue disease | 62 | 3.326 | 1.7 |
| Norwegian scabies | 1 | 3.0 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| group 3 medulloblastoma | 1.500 | 7.0e-05 |
| primitive neuroectodermal tumor | 1.100 | 1.3e-02 |
