| Tbio | COUP transcription factor 1 |
Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG.
The protein encoded by this gene is a nuclear hormone receptor and transcriptional regulator. The encoded protein acts as a homodimer and binds to 5'-AGGTCA-3' repeats. Defects in this gene are a cause of Bosch-Boonstra optic atrophy syndrome (BBOAS). [provided by RefSeq, Apr 2014]
The protein encoded by this gene is a nuclear hormone receptor and transcriptional regulator. The encoded protein acts as a homodimer and binds to 5'-AGGTCA-3' repeats. Defects in this gene are a cause of Bosch-Boonstra optic atrophy syndrome (BBOAS). [provided by RefSeq, Apr 2014]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Bosch-Boonstra-Schaaf optic atrophy syndrome | 2 | 0.0 | 0.0 |
| Breast Neoplasms | 445 | 0.0 | 0.0 |
| Ovarian Cysts | 41 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 2.3e-23 |
| lung carcinoma | 2843 | 1.9e-17 |
| malignant mesothelioma | 3232 | 3.0e-09 |
| ovarian cancer | 8520 | 5.8e-09 |
| adrenocortical carcinoma | 1428 | 3.0e-06 |
| cystic fibrosis | 1696 | 9.1e-06 |
| breast carcinoma | 1638 | 3.1e-05 |
| pituitary cancer | 1972 | 1.1e-04 |
| Atopic dermatitis | 952 | 1.1e-03 |
| lung cancer | 4740 | 1.7e-03 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 2.1e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 2.6e-03 |
| urothelial carcinoma | 318 | 8.9e-03 |
| osteosarcoma | 7950 | 1.2e-02 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 2.3e-02 |
| astrocytoma | 1146 | 2.7e-02 |
| head and neck cancer | 271 | 3.3e-02 |
| group 3 medulloblastoma | 4104 | 3.4e-02 |
| invasive ductal carcinoma | 2951 | 4.5e-02 |
| spina bifida | 1074 | 5.0e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Autosomal dominant nonsyndromic deafness 15 | 5 | 3.551 | 1.8 |
| Congenital diaphragmatic hernia | 67 | 3.224 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| adrenocortical carcinoma | -2.341 | 3.0e-06 |
| astrocytoma | 1.500 | 2.7e-02 |
| Atopic dermatitis | -1.200 | 1.1e-03 |
| breast carcinoma | -1.700 | 3.1e-05 |
| cystic fibrosis | -1.226 | 9.1e-06 |
| group 3 medulloblastoma | -1.400 | 3.4e-02 |
| head and neck cancer | -1.300 | 3.3e-02 |
| intraductal papillary-mucinous adenoma (... | -2.500 | 2.1e-03 |
| intraductal papillary-mucinous carcinoma... | -2.700 | 2.6e-03 |
| intraductal papillary-mucinous neoplasm ... | -2.400 | 2.3e-02 |
| invasive ductal carcinoma | -1.096 | 4.5e-02 |
| lung cancer | -1.500 | 1.7e-03 |
| lung carcinoma | -1.300 | 1.9e-17 |
| malignant mesothelioma | -4.000 | 3.0e-09 |
| non-small cell lung cancer | -1.641 | 2.3e-23 |
| osteosarcoma | -2.489 | 1.2e-02 |
| ovarian cancer | -4.500 | 5.8e-09 |
| pituitary cancer | -1.400 | 1.1e-04 |
| spina bifida | 1.461 | 5.0e-02 |
| urothelial carcinoma | 2.200 | 8.9e-03 |
MAMVVSSWRDPQDDVAGGNPGGPNPAAQAARGGGGGAGEQQQQAGSGAPHTPQTPGQPGAPATPGTAGDK 1 - 70 GQGPPGSGQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQY 71 - 140 CRLKKCLKVGMRREAVQRGRMPPTQPNPGQYALTNGDPLNGHCYLSGYISLLLRAEPYPTSRYGSQCMQP 141 - 210 NNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAA 211 - 280 GLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQC 281 - 350 ALEEYVRSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMSI 351 - 420 QCS 421 - 423 //
