| Tbio | C-type natriuretic peptide |
Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity).
This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cardiac natriuretic peptides CNP-53, CNP-29 and CNP-22, which belong to the natriuretic family of peptides. The encoded peptides exhibit vasorelaxation activity in laboratory animals and elevated levels of CNP-22 have been observed in the plasma of chronic heart failure patients. [provided by RefSeq, Oct 2015]
This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cardiac natriuretic peptides CNP-53, CNP-29 and CNP-22, which belong to the natriuretic family of peptides. The encoded peptides exhibit vasorelaxation activity in laboratory animals and elevated levels of CNP-22 have been observed in the plasma of chronic heart failure patients. [provided by RefSeq, Oct 2015]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Ureteral obstruction | 33 | 3.034 | 1.5 |
| Bone Diseases, Developmental | 27 | 0.0 | 0.0 |
| Cartilage Diseases | 6 | 0.0 | 0.0 |
| Growth Disorders | 35 | 0.0 | 0.0 |
| Hyperkinesis | 32 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Hyperactive behavior | 91 |
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 5.9e-07 |
| Astrocytoma, Pilocytic | 3081 | 8.0e-07 |
| medulloblastoma, large-cell | 6241 | 1.9e-05 |
| group 4 medulloblastoma | 1855 | 1.0e-04 |
| adult high grade glioma | 3801 | 4.0e-04 |
| fibroadenoma | 559 | 2.6e-03 |
| posterior fossa group A ependymoma | 468 | 1.3e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Acromesomelic dysplasia | 10 | 5.987 | 3.0 |
| Achondroplasia | 21 | 5.244 | 2.6 |
| Hypertension | 396 | 4.175 | 2.1 |
| Heart disease | 306 | 3.965 | 2.0 |
| Paraphimosis | 1 | 3.569 | 1.8 |
| Coronary artery disease | 268 | 3.315 | 1.7 |
| Hypochondroplasia | 10 | 3.164 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.100 | 4.0e-04 |
| Astrocytoma, Pilocytic | -1.100 | 8.0e-07 |
| fibroadenoma | 1.100 | 2.6e-03 |
| group 4 medulloblastoma | -1.300 | 1.0e-04 |
| medulloblastoma, large-cell | -1.100 | 1.9e-05 |
| posterior fossa group A ependymoma | 1.300 | 1.3e-02 |
| psoriasis | -1.100 | 5.9e-07 |
