Property Summary

NCBI Gene PubMed Count 19
PubMed Score 123.59
PubTator Score 63.57

Knowledge Summary


No data available


  Disease (2)

Gene RIF (13)

25403753 Results show that neurogenin-1 and -2 drive homogeneous differentiation of human stem cells into bipolar neurons in 4 days in defined media.
23419067 We propose NEUROG1 as a new gene for syndromic autosomal recessive hearing loss and congenital cranial dysinnervation disorder
23034738 Methylation of NEUROG1 is associated with recurrence following adjuvant FOLFOX in Stages II/III colorectal cancer.
21326223 NEUROG1 gene is frequently found in patients, diagnosed with colorectal cancer.
20102160 The basic helix-loop-helix region of human neurogenin 1 is a monomeric natively unfolded protein which forms a "fuzzy" complex upon DNA binding.
19813087 Stable expression of a single gene Ngn1 in F3 cells induces not simply neurogenic but multifunctional changes that potentially affect the differentiation of human NSC via a reorganization of complex gene regulatory networks.
19086053 Observational study of gene-disease association. (HuGE Navigator)
18799289 Major alleles on two NEUROG1-associated SNPs (rs2344484-C-allele and rs8192558-G-allele) were significantly more prevalent among patients. this is the first study to examine brain morphological and neurocognitive correlates of NEUROG1.
18799289 Observational study of gene-disease association. (HuGE Navigator)
18053270 Observational study of gene-disease association. (HuGE Navigator)
17044100 Observational study of gene-disease association. (HuGE Navigator)
17044100 These results, along with a priori evidence for the involvement of neurog1 in neurodevelopment, suggest that variants in neurog1 might have a small effect on susceptibility to schizophrenia.
12526089 Overexpression of the full-length Ngn1 induced neurite outgrowth in F11 cells in the absence of cAMP

AA Sequence

RPGDPVFSFPSLPKDLLHTTPCFIPYH                                               211 - 237

Text Mined References (19)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
25403753 2014 Rapid neurogenesis through transcriptional activation in human stem cells.
23419067 2013 A boy with homozygous microdeletion of NEUROG1 presents with a congenital cranial dysinnervation disorder [Moebius syndrome variant].
23034738 2013 Methylation and microsatellite status and recurrence following adjuvant FOLFOX in colorectal cancer.
21697133 2011 Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.
21326223 2011 Methylation of NEUROG1 in serum is a sensitive marker for the detection of early colorectal cancer.
20102160 2010 The basic helix-loop-helix region of human neurogenin 1 is a monomeric natively unfolded protein which forms a "fuzzy" complex upon DNA binding.
19813087 2010 Stable expression of neurogenin 1 induces LGR5, a novel stem cell marker, in an immortalized human neural stem cell line HB1.F3.
19086053 2009 Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.
18799289 2008 Basic helix-loop-helix transcription factor NEUROG1 and schizophrenia: effects on illness susceptibility, MRI brain morphometry and cognitive abilities.
18053270 2007 Association of autism with polymorphisms in the paired-like homeodomain transcription factor 1 (PITX1) on chromosome 5q31: a candidate gene analysis.
17044100 2007 Association between the 5q31.1 gene neurogenin1 and schizophrenia.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
12526089 2002 Overexpression of neurogenin1 induces neurite outgrowth in F11 neuroblastoma cells.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11732772 2001 NeuroD homologue expression during cortical development in the human brain.
11239394 2001 Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms.
9119405 1997 NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectively.
8816493 1996 NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family.