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Tclin NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

 Comments

Property Summary

NCBI Gene PubMed Count 16
PubMed Score 3.21
PubTator Score 2.01

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Expression

  Differential Expression (3)

Disease log2 FC p
pancreatic ductal adenocarcinoma liver m... -1.915 6.9e-03
non primary Sjogren syndrome sicca 1.400 3.1e-02
ovarian cancer 2.000 1.1e-05

Synonym

Accession O96000 Q96II6
Symbols PDSW

Gene

NDUFB10

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG Inparanoid

 UniProt Keyword (10)

 GO Function (1)

 GO Component (3)

 GO Process (2)

 Compartment GO Term (45)

See all...

 HCA RNA Cell Line (56)

See all...

Pathway (15)

See all...

Protein-protein Interaction (54)

NDUFS8   UQCRQ   UQCR11   NDUFA1   NDUFS4   NDUFB5   NDUFC1   NDUFS5   NDUFS7   NDUFS2   NDUFS6   NDUFB1   NDUFS3   NDUFB2   SLC25A14   NDUFA10   SLC25A27   MT-ND1   MT-ND2   MT-ND3   MT-ND4   MT-ND5   MT-ND6   UQCRH   UQCRB   NDUFV2   UQCRC2   UCP1   NDUFS1   UQCRC1   DLST   UQCRFS1   NDUFV1   NDUFA8   UCP2   UCP3   NDUFV3   OGDH   NNT   NDUFA5   NDUFA9   NDUFAF6   NDUFAF5   NDUFAF7   NDUFA11   TMEM126B   NDUFAF2   ECSIT   NDUFAF3   ACAD9   TIMMDC1   NDUFB11   NDUFAF4   UQCR10  

Drug (1)

Structure of metformin

metformin

Ligand (1)

Structure of CHEMBL1258701

CHEMBL1258701
pIC50 8.24

Gene RIF (4)

PMID Text
22321370 Src kinase inhibition led to a decrease in mitochondrial respiration via a specific decrease in complex I activities which is associated with a lower phosphorylation of the complex I subunit NDUFB10.
20877624 Observational study of gene-disease association. (HuGE Navigator)
18977241 Observational study of gene-disease association. (HuGE Navigator)
17601350 Observational study of gene-disease association. (HuGE Navigator)

AA Sequence 

MPDSWDKDVYPEPPRRTPVQPNPIVYMMKAFDLIVDRPVTLVREFIERQHAKNRYYYYHRQYRRVPDITE      1 - 70
CKEEDIMCMYEAEMQWKRDYKVDQEIINIMQDRLKACQQREGQNYQQNCIKEVEQFTQVAKAYQDRYQDL     71 - 140
GAYSSARKCLAKQRQRMLQERKAAKEAAAATS                                          141 - 172
//

Text Mined References (21)

PMID Year Title
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25416956 2014 A proteome-scale map of the human interactome network.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22321370 2012 Preservation of NADH ubiquinone-oxidoreductase activity by Src kinase-mediated phosphorylation of NDUFB10.
21269460 2011 Initial characterization of the human central proteome.
20877624 2010 Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
18977241 2008 Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey.
17601350 2007 A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.
16537434 2006 p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling.
15616553 2004 The sequence and analysis of duplication-rich human chromosome 16.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15342556 2004 Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.
14557246 2003 AIP is a mitochondrial import mediator that binds to both import receptor Tom20 and preproteins.
12611891 2003 The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11157797 2001 Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.
11042152 2000 Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.
9878551 1998 cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed.
9763677 1998 Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain.