1. Home
  2. Targets
  3. Condensin complex subunit 3

Tbio Condensin complex subunit 3

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

This gene encodes a subunit of the condensin complex, which is responsible for the condensation and stabilization of chromosomes during mitosis and meiosis. Phosphorylation of the encoded protein activates the condensin complex. There are pseudogenes for this gene on chromosomes 8 and 15. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

 Comments

Property Summary

NCBI Gene PubMed Count 23
PubMed Score 36.14
PubTator Score 6.46

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.9
Kidney cancer 2613 0.0 0.6
Disease Target Count Z-score Confidence
Croup 12 3.413 1.7

Expression

  Differential Expression (30)

Disease log2 FC p
adrenocortical carcinoma 1.752 1.4e-04
adult high grade glioma 1.600 3.5e-03
Atopic dermatitis 2.500 1.4e-05
atypical teratoid / rhabdoid tumor 2.200 2.6e-08
Breast cancer 2.300 2.7e-02
breast carcinoma 2.100 4.4e-06
colon cancer 1.200 1.4e-02
ductal carcinoma in situ 1.600 1.7e-03
Endometriosis 1.484 4.7e-02
ependymoma 1.100 3.2e-04
glioblastoma 2.300 5.2e-09
group 3 medulloblastoma 3.800 7.2e-08
interstitial cystitis 1.100 6.0e-03
intraductal papillary-mucinous carcinoma... 2.700 5.4e-05
intraductal papillary-mucinous neoplasm ... 3.200 4.0e-05
invasive ductal carcinoma 2.000 2.1e-03
lung adenocarcinoma 1.100 1.1e-06
lung cancer 3.100 1.5e-05
malignant mesothelioma 1.100 1.2e-06
medulloblastoma, large-cell 2.900 4.4e-07
nasopharyngeal carcinoma 1.700 1.3e-05
non-small cell lung cancer 2.292 6.0e-25
osteosarcoma -3.259 3.0e-03
ovarian cancer 2.200 5.8e-06
pancreatic cancer 1.200 6.7e-03
pancreatic carcinoma 1.200 6.7e-03
pancreatic ductal adenocarcinoma liver m... 1.559 3.7e-02
primary Sjogren syndrome 1.100 9.8e-03
primitive neuroectodermal tumor 2.700 1.1e-05
psoriasis -1.300 1.0e-02

Synonym

Accession Q9BPX3 Q3MJE0 Q96SV9 Q9BUR3 Q9BVY1 Q9H914 Q9H9Z6 Q9HBI9
Symbols CAPG
CHCG
YCG1
NY-MEL-3

Gene

NCAPG

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (12)

See all...

 GO Component (6)

 GO Process (2)

 Compartment GO Term (25)

See all...

 GWAS Trait (1)

 HCA RNA Cell Line (56)

See all...

Pathway (6)

Protein-protein Interaction (1)

ARRDC1  

Gene RIF (3)

AA Sequence 

MGAERRLLSIKEAFRLAQQPHQNQAKLVVALSRTYRTMDDKTVFHEEFIHYLKYVMVVYKREPAVERVIE      1 - 70
FAAKFVTSFHQSDMEDDEEEEDGGLLNYLFTFLLKSHEANSNAVRFRVCLLINKLLGSMPENAQIDDDVF     71 - 140
DKINKAMLIRLKDKIPNVRIQAVLALSRLQDPKDDECPVVNAYATLIENDSNPEVRRAVLSCIAPSAKTL    141 - 210
PKIVGRTKDVKEAVRKLAYQVLAEKVHMRAMSIAQRVMLLQQGLNDRSDAVKQAMQKHLLQGWLRFSEGN    211 - 280
ILELLHRLDVENSSEVAVSVLNALFSITPLSELVGLCKNNDGRKLIPVETLTPEIALYWCALCEYLKSKG    281 - 350
DEGEEFLEQILPEPVVYADYLLSYIQSIPVVNEEHRGDFSYIGNLMTKEFIGQQLILIIKSLDTSEEGGR    351 - 420
KKLLAVLQEILILPTIPISLVSFLVERLLHIIIDDNKRTQIVTEIISEIRAPIVTVGVNNDPADVRKKEL    421 - 490
KMAEIKVKLIEAKEALENCITLQDFNRASELKEEIKALEDARINLLKETEQLEIKEVHIEKNDAETLQKC    491 - 560
LILCYELLKQMSISTGLSATMNGIIESLILPGIISIHPVVRNLAVLCLGCCGLQNQDFARKHFVLLLQVL    561 - 630
QIDDVTIKISALKAIFDQLMTFGIEPFKTKKIKTLHCEGTEINSDDEQESKEVEETATAKNVLKLLSDFL    631 - 700
DSEVSELRTGAAEGLAKLMFSGLLVSSRILSRLILLWYNPVTEEDVQLRHCLGVFFPVFAYASRTNQECF    701 - 770
EEAFLPTLQTLANAPASSPLAEIDITNVAELLVDLTRPSGLNPQAKTSQDYQALTVHDNLAMKICNEILT    771 - 840
SPCSPEIRVYTKALSSLELSSHLAKDLLVLLNEILEQVKDRTCLRALEKIKIQLEKGNKEFGDQAEAAQD    841 - 910
ATLTTTTFQNEDEKNKEVYMTPLRGVKATQASKSTQLKTNRGQRKVTVSARTNRRCQTAEADSESDHEVP    911 - 980
EPESEMKMRLPRRAKTAALEKSKLNLAQFLNEDLS                                       981 - 1015
//

Text Mined References (34)

PMID Year Title