| Tbio | Nucleosome assembly protein 1-like 4 |
Acts as histone chaperone in nucleosome assembly.
This gene encodes a member of the nucleosome assembly protein (NAP) family which can interact with both core and linker histones. It can shuttle between the cytoplasm and nucleus, suggesting a role as a histone chaperone. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. [provided by RefSeq, Jul 2008]
This gene encodes a member of the nucleosome assembly protein (NAP) family which can interact with both core and linker histones. It can shuttle between the cytoplasm and nucleus, suggesting a role as a histone chaperone. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count |
|---|---|
| Alcoholic Intoxication, Chronic | 283 |
| Disease | Target Count | P-value |
|---|---|---|
| osteosarcoma | 7766 | 4.5e-06 |
| ovarian cancer | 8297 | 6.7e-04 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2902 | 8.2e-04 |
| lung cancer | 4607 | 1.3e-03 |
| group 3 medulloblastoma | 4002 | 1.7e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3204 | 3.3e-03 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Hemolytic anemia | 73 | 0.0 | 2.8 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Beckwith-Wiedemann syndrome | 44 | 5.4 | 2.7 |
| Nephroblastoma | 50 | 3.172 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| group 3 medulloblastoma | 1.100 | 1.7e-03 |
| intraductal papillary-mucinous carcinoma... | 1.100 | 8.2e-04 |
| intraductal papillary-mucinous neoplasm ... | 1.300 | 3.3e-03 |
| lung cancer | 1.200 | 1.3e-03 |
| osteosarcoma | -1.327 | 4.5e-06 |
| ovarian cancer | 1.100 | 6.7e-04 |
MADHSFSDGVPSDSVEAAKNASNTEKLTDQVMQNPRVLAALQERLDNVPHTPSSYIETLPKAVKRRINAL 1 - 70 KQLQVRCAHIEAKFYEEVHDLERKYAALYQPLFDKRREFITGDVEPTDAESEWHSENEEEEKLAGDMKSK 71 - 140 VVVTEKAAATAEEPDPKGIPEFWFTIFRNVDMLSELVQEYDEPILKHLQDIKVKFSDPGQPMSFVLEFHF 141 - 210 EPNDYFTNSVLTKTYKMKSEPDKADPFSFEGPEIVDCDGCTIDWKKGKNVTVKTIKKKQKHKGRGTVRTI 211 - 280 TKQVPNESFFNFFNPLKASGDGESLDEDSEFTLASDFEIGHFFRERIVPRAVLYFTGEAIEDDDNFEEGE 281 - 350 EGEEEELEGDEEGEDEDDAEINPKV 351 - 375 //
