You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MYT1L
Myelin transcription factor 1-like protein

Protein Summary
Description
Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non-neuronal genes during neuron differentiation. In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs. Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B. The 5'-AAGTT-3' core motif is absent from the promoter of neural genes. This gene encodes a member of the zinc finger superfamily of transcription factors whose expression, thus far, has been found only in neuronal tissues. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399161
  • ENSP00000382114
  • ENSG00000186487
  • ENST00000407844
  • ENSP00000384219
  • ENST00000428368
  • ENSP00000396103
  • ENST00000647694
  • ENSP00000497722
  • ENST00000647738
  • ENSP00000497479
  • ENST00000648316
  • ENSP00000497870
  • ENST00000648928
  • ENSP00000497017
  • ENST00000649207
  • ENSP00000496986

Symbol
  • KIAA1106
  • NZF1
  • MRD39
  • myT1-L
  • ZC2H2C2
  • ZC2HC4B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
trait
0.86
transcription factor perturbation
0.68
disease
0.63
cell line
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.8   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 53   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.8   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0