| Tdark | 39S ribosomal protein L20, mitochondrial |
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 21q. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| osteosarcoma | 7950 | 2.8e-07 |
| psoriasis | 6694 | 3.9e-05 |
| ovarian cancer | 8520 | 1.5e-03 |
| dermatomyositis | 966 | 1.5e-03 |
| breast carcinoma | 1638 | 1.1e-02 |
| acute myeloid leukemia | 783 | 3.6e-02 |
| Disease | log2 FC | p |
|---|---|---|
| acute myeloid leukemia | -1.500 | 3.6e-02 |
| breast carcinoma | 1.400 | 1.1e-02 |
| dermatomyositis | 1.600 | 1.5e-03 |
| osteosarcoma | -2.411 | 2.8e-07 |
| ovarian cancer | 1.700 | 1.5e-03 |
| psoriasis | -2.900 | 3.9e-05 |
