Tbio MLIP Muscular LMNA-interacting protein

Protein Summary

Description

Required for precocious cardiac adaptation to stress through integrated regulation of the AKT/mTOR pathways and FOXO1. Regulates cardiac homeostasis and plays an important role in protection against cardiac hypertrophy. Acts as a transcriptional cofactor, represses transactivator activity of ISL1 and MYOCD.

Uniprot Accession IDs

• Q5VWP3
• B7Z2N0
• D6RE05
• Q96H08
• Q96NF7

Gene Name

• MLIP

Ensembl ID

• ENST00000274897
• ENSP00000274897
• ENSG00000146147
• ENST00000370876
• ENSP00000359913
• ENST00000502396
• ENSP00000426290
• ENST00000514921
• ENSP00000425142

Symbol

• C6orf142
• Cip
• CIP
• C6orf142

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.75
virus perturbation	0.64
small molecule perturbation	0.53
tissue sample	0.52
cellular component	0.51

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.97   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 50   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.97   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0