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Tbio
MLH1
DNA mismatch repair protein Mlh1

Protein Summary
Description
Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in c ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000231790
  • ENSP00000231790
  • ENSG00000076242
  • ENST00000435176
  • ENSP00000402564
  • ENST00000455445
  • ENSP00000398272
  • ENST00000458205
  • ENSP00000402667
  • ENST00000536378
  • ENSP00000444286
  • ENST00000539477
  • ENSP00000443665

Symbol
  • COCA2
  • FCC2
  • COCA2
  • HNPCC
  • hMLH1
  • HNPCC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
molecular function
0.99
kinase perturbation
0.93
protein domain
0.92
biological process
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3452.29   (req: < 5)
Gene RIFs: 769   (req: <= 3)
Antibodies: 654   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3452.29   (req: >= 5)
Gene RIFs: 769   (req: > 3)
Antibodies: 654   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0