| Tbio | Transport and Golgi organization protein 1 homolog |
Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:27138255).
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Coronary artery disease | 268 | 3.126 | 1.6 |
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 1.8e-06 |
| medulloblastoma, large-cell | 6241 | 5.3e-05 |
| ovarian cancer | 8520 | 2.1e-04 |
| atypical teratoid / rhabdoid tumor | 5112 | 2.5e-04 |
| lung cancer | 4740 | 5.8e-04 |
| diabetes mellitus | 1728 | 1.3e-03 |
| group 4 medulloblastoma | 1855 | 2.5e-03 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 6.1e-03 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 8.2e-03 |
| glioblastoma | 5792 | 9.4e-03 |
| Pick disease | 1894 | 9.6e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 1.5e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Cardiovascular system disease | 246 | 0.0 | 1.7 |
| Myocardial Infarction | 151 | 0.0 | 3.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Alcoholic neuropathy | 3 | 4.147 | 2.1 |
| Disease | log2 FC | p |
|---|---|---|
| atypical teratoid / rhabdoid tumor | -1.200 | 2.5e-04 |
| diabetes mellitus | -1.100 | 1.3e-03 |
| glioblastoma | -1.100 | 9.4e-03 |
| group 4 medulloblastoma | 1.100 | 2.5e-03 |
| intraductal papillary-mucinous adenoma (... | 1.200 | 8.2e-03 |
| intraductal papillary-mucinous carcinoma... | 1.100 | 1.5e-02 |
| lung cancer | 1.200 | 5.8e-04 |
| medulloblastoma, large-cell | 1.200 | 5.3e-05 |
| ovarian cancer | -1.200 | 2.1e-04 |
| pancreatic ductal adenocarcinoma liver m... | -1.082 | 6.1e-03 |
| Pick disease | -1.100 | 9.6e-03 |
| psoriasis | -1.100 | 1.8e-06 |
| Species | Source | Disease |
|---|---|---|
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG |
MAAAPGLLVWLLVLRLPWRVPGQLDPSTGRRFSEHKLCADDECSMLMYRGEALEDFTGPDCRFVNFKKGD 1 - 70 PVYVYYKLARGWPEVWAGSVGRTFGYFPKDLIQVVHEYTKEELQVPTDETDFVCFDGGRDDFHNYNVEEL 71 - 140 LGFLELYNSAATDSEKAVEKTLQDMEKNPELSKEREPEPEPVEANSEESDSVFSENTEDLQEQFTTQKHH 141 - 210 SHANSQANHAQGEQASFESFEEMLQDKLKVPESENNKTSNSSQVSNEQDKIDAYKLLKKEMTLDLKTKFG 211 - 280 STADALVSDDETTRLVTSLEDDFDEELDTEYYAVGKEDEENQEDFDELPLLTFTDGEDMKTPAKSGVEKY 281 - 350 PTDKEQNSNEEDKVQLTVPPGIKNDDKNILTTWGDTIFSIVTGGEETRDTMDLESSSSEEEKEDDDDALV 351 - 420 PDSKQGKPQSATDYSDPDNVDDGLFIVDIPKTNNDKEVNAEHHIKGKGRGVQESKRGLVQDKTELEDENQ 421 - 490 EGMTVHSSVHSNNLNSMPAAEKGKDTLKSAYDDTENDLKGAAIHISKGMLHEEKPGEQILEGGSESESAQ 491 - 560 KAAGNQMNDRKIQQESLGSAPLMGDDHPNASRDSVEGDALVNGAKLHTLSVEHQREELKEELVLKTQNQP 561 - 630 RFSSPDEIDLPRELEDEVPILGRNLPWQQERDVAATASKQMSEKIRLSEGEAKEDSLDEEFFHHKAMQGT 631 - 700 EVGQTDQTDSTGGPAFLSKVEEDDYPSEELLEDENAINAKRSKEKNPGNQGRQFDVNLQVPDRAVLGTIH 701 - 770 PDPEIEESKQETSMILDSEKTSETAAKGVNTGGREPNTMVEKERPLADKKAQRPFERSDFSDSIKIQTPE 771 - 840 LGEVFQNKDSDYLKNDNPEEHLKTSGLAGEPEGELSKEDHENTEKYMGTESQGSAAAEPEDDSFHWTPHT 841 - 910 SVEPGHSDKREDLLIISSFFKEQQSLQRFQKYFNVHELEALLQEMSSKLKSAQQESLPYNMEKVLDKVFR 911 - 980 ASESQILSIAEKMLDTRVAENRDLGMNENNIFEEAAVLDDIQDLIYFVRYKHSTAEETATLVMAPPLEEG 981 - 1050 LGGAMEEMQPLHEDNFSREKTAELNVQVPEEPTHLDQRVIGDTHASEVSQKPNTEKDLDPGPVTTEDTPM 1051 - 1120 DAIDANKQPETAAEEPASVTPLENAILLIYSFMFYLTKSLVATLPDDVQPGPDFYGLPWKPVFITAFLGI 1121 - 1190 ASFAIFLWRTVLVVKDRVYQVTEQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSD 1191 - 1260 EAIKYKDKIKTLEKNQEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQI 1261 - 1330 ALNEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEKSQKDLEVALTHKDD 1331 - 1400 NINALTNCITQLNLLECESESEGQNKGGNDSDELANGEVGGDRNEKMKNQIKQMMDVSRTQTAISVVEED 1401 - 1470 LKLLQLKLRASVSTKCNLEDQVKKLEDDRNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQ 1471 - 1540 EEYERQEREHRLSAADEKAVSAAEEVKTYKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKARAAER 1541 - 1610 AIAEEKREAANLRHKLLELTQKMAMLQEEPVIVKPMPGKPNTQNPPRRGPLSQNGSFGPSPVSGGECSPP 1611 - 1680 LTVEPPVRPLSATLNRRDMPRSEFGSVDGPLPHPRWSAEASGKPSPSDPGSGTATMMNSSSRGSSPTRVL 1681 - 1750 DEGKVNMAPKGPPPFPGVPLMSTPMGGPVPPPIRYGPPPQLCGPFGPRPLPPPFGPGMRPPLGLREFAPG 1751 - 1820 VPPGRRDLPLHPRGFLPGHAPFRPLGSLGPREYFIPGTRLPPPTHGPQEYPPPPAVRDLLPSGSRDEPPP 1821 - 1890 ASQSTSQDCSQALKQSP 1891 - 1907 //
