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Tbio Transport and Golgi organization protein 1 homolog

Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:27138255).

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Property Summary

NCBI Gene PubMed Count 32
PubMed Score 30.05
PubTator Score 29.77

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (5)

Disease Target Count Z-score Confidence
Coronary artery disease 268 3.126 1.6
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 1.2
Kidney cancer 2613 0.0 0.7
Disease Target Count Z-score Confidence
Cardiovascular system disease 246 0.0 1.7
Myocardial Infarction 151 0.0 3.0
Disease Target Count Z-score Confidence
Alcoholic neuropathy 3 4.147 2.1

Expression

  Differential Expression (12)

Disease log2 FC p
atypical teratoid / rhabdoid tumor -1.200 2.5e-04
diabetes mellitus -1.100 1.3e-03
glioblastoma -1.100 9.4e-03
group 4 medulloblastoma 1.100 2.5e-03
intraductal papillary-mucinous adenoma (... 1.200 8.2e-03
intraductal papillary-mucinous carcinoma... 1.100 1.5e-02
lung cancer 1.200 5.8e-04
medulloblastoma, large-cell 1.200 5.3e-05
ovarian cancer -1.200 2.1e-04
pancreatic ductal adenocarcinoma liver m... -1.082 6.1e-03
Pick disease -1.100 9.6e-03
psoriasis -1.100 1.8e-06

Synonym

Accession Q5JRA6 A8K2S0 A8MT05 A8MT13 B7Z430 Q14083 Q3S4X3 Q5JRA5 Q5JRB0 Q5JRB1 Q5JRB2 Q6UVY8 Q86Y60 Q8N8M5 Q92580 TANGO1
Symbols ARNT
D320
TANGO
TANGO1
UNQ6077

Gene

MIA3

PANTHER Protein Class (2)

PDB

5KYU   5KYW   5KYN  

  Ortholog (1)

Species Source Disease
Macaque OMA EggNOG Inparanoid

 UniProt Keyword (19)

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 GO Function (1)

 GO Component (6)

 GO Process (11)

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 Compartment GO Term (30)

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 MGI Phenotype (10)

 GWAS Trait (6)

 HCA RNA Cell Line (56)

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 CSPA Cell Line (9)

Pathway (10)

Protein-protein Interaction (2)

CRTAP   SIGLEC12  

Gene RIF (17)

AA Sequence 

MAAAPGLLVWLLVLRLPWRVPGQLDPSTGRRFSEHKLCADDECSMLMYRGEALEDFTGPDCRFVNFKKGD      1 - 70
PVYVYYKLARGWPEVWAGSVGRTFGYFPKDLIQVVHEYTKEELQVPTDETDFVCFDGGRDDFHNYNVEEL     71 - 140
LGFLELYNSAATDSEKAVEKTLQDMEKNPELSKEREPEPEPVEANSEESDSVFSENTEDLQEQFTTQKHH    141 - 210
SHANSQANHAQGEQASFESFEEMLQDKLKVPESENNKTSNSSQVSNEQDKIDAYKLLKKEMTLDLKTKFG    211 - 280
STADALVSDDETTRLVTSLEDDFDEELDTEYYAVGKEDEENQEDFDELPLLTFTDGEDMKTPAKSGVEKY    281 - 350
PTDKEQNSNEEDKVQLTVPPGIKNDDKNILTTWGDTIFSIVTGGEETRDTMDLESSSSEEEKEDDDDALV    351 - 420
PDSKQGKPQSATDYSDPDNVDDGLFIVDIPKTNNDKEVNAEHHIKGKGRGVQESKRGLVQDKTELEDENQ    421 - 490
EGMTVHSSVHSNNLNSMPAAEKGKDTLKSAYDDTENDLKGAAIHISKGMLHEEKPGEQILEGGSESESAQ    491 - 560
KAAGNQMNDRKIQQESLGSAPLMGDDHPNASRDSVEGDALVNGAKLHTLSVEHQREELKEELVLKTQNQP    561 - 630
RFSSPDEIDLPRELEDEVPILGRNLPWQQERDVAATASKQMSEKIRLSEGEAKEDSLDEEFFHHKAMQGT    631 - 700
EVGQTDQTDSTGGPAFLSKVEEDDYPSEELLEDENAINAKRSKEKNPGNQGRQFDVNLQVPDRAVLGTIH    701 - 770
PDPEIEESKQETSMILDSEKTSETAAKGVNTGGREPNTMVEKERPLADKKAQRPFERSDFSDSIKIQTPE    771 - 840
LGEVFQNKDSDYLKNDNPEEHLKTSGLAGEPEGELSKEDHENTEKYMGTESQGSAAAEPEDDSFHWTPHT    841 - 910
SVEPGHSDKREDLLIISSFFKEQQSLQRFQKYFNVHELEALLQEMSSKLKSAQQESLPYNMEKVLDKVFR    911 - 980
ASESQILSIAEKMLDTRVAENRDLGMNENNIFEEAAVLDDIQDLIYFVRYKHSTAEETATLVMAPPLEEG    981 - 1050
LGGAMEEMQPLHEDNFSREKTAELNVQVPEEPTHLDQRVIGDTHASEVSQKPNTEKDLDPGPVTTEDTPM   1051 - 1120
DAIDANKQPETAAEEPASVTPLENAILLIYSFMFYLTKSLVATLPDDVQPGPDFYGLPWKPVFITAFLGI   1121 - 1190
ASFAIFLWRTVLVVKDRVYQVTEQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSD   1191 - 1260
EAIKYKDKIKTLEKNQEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQI   1261 - 1330
ALNEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQIKSFEKSQKDLEVALTHKDD   1331 - 1400
NINALTNCITQLNLLECESESEGQNKGGNDSDELANGEVGGDRNEKMKNQIKQMMDVSRTQTAISVVEED   1401 - 1470
LKLLQLKLRASVSTKCNLEDQVKKLEDDRNSLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQ   1471 - 1540
EEYERQEREHRLSAADEKAVSAAEEVKTYKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKARAAER   1541 - 1610
AIAEEKREAANLRHKLLELTQKMAMLQEEPVIVKPMPGKPNTQNPPRRGPLSQNGSFGPSPVSGGECSPP   1611 - 1680
LTVEPPVRPLSATLNRRDMPRSEFGSVDGPLPHPRWSAEASGKPSPSDPGSGTATMMNSSSRGSSPTRVL   1681 - 1750
DEGKVNMAPKGPPPFPGVPLMSTPMGGPVPPPIRYGPPPQLCGPFGPRPLPPPFGPGMRPPLGLREFAPG   1751 - 1820
VPPGRRDLPLHPRGFLPGHAPFRPLGSLGPREYFIPGTRLPPPTHGPQEYPPPPAVRDLLPSGSRDEPPP   1821 - 1890
ASQSTSQDCSQALKQSP                                                        1891 - 1907
//

Text Mined References (44)

PMID Year Title