| Tbio | E3 ubiquitin-protein ligase MGRN1 |
E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination.
Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro.[supplied by OMIM, Apr 2004]
Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro.[supplied by OMIM, Apr 2004]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 3.2e-08 |
| psoriasis | 6694 | 2.4e-04 |
| breast carcinoma | 1638 | 3.7e-04 |
| osteosarcoma | 7950 | 7.9e-04 |
| astrocytoma | 1146 | 3.7e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Prion disease | 16 | 3.424 | 1.7 |
| Congenital heart disease | 93 | 3.372 | 1.7 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytoma | 1.100 | 3.7e-02 |
| breast carcinoma | 1.200 | 3.7e-04 |
| osteosarcoma | -1.152 | 7.9e-04 |
| ovarian cancer | -1.100 | 3.2e-08 |
| psoriasis | -1.700 | 2.4e-04 |
MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDLNFLGSRPVQF 1 - 70 PYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSLEFTFDADARVAITIYCQASE 71 - 140 EFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDFSEWKDDELNFDLDRGVFPVVIQAVVDEGDV 141 - 210 VEVTGHAHVLLAAFEKHMDGSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVV 211 - 280 CLSDLRDTLILPCRHLCLCTSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLE 281 - 350 HDEHSCPFKKSKPHPASLASKKPKRETNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGIS 351 - 420 DGLSQASCPLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEEKLSEDVDAPPPLGGAELALRES 421 - 490 SSPESFITEEVDESSSPQQGTRAASIENVLQDSSPEHCGRGPPADIYLPALGPDSCSVGIDE 491 - 552 //
