| Tbio | Major facilitator superfamily domain-containing protein 8 |
May be a carrier that transport small solutes by using chemiosmotic ion gradients.
This gene encodes a ubiquitous integral membrane protein that contains a transporter domain and a major facilitator superfamily (MFS) domain. Other members of the major facilitator superfamily transport small solutes through chemiosmotic ion gradients. The substrate transported by this protein is unknown. The protein likely localizes to lysosomal membranes. Mutations in this gene are correlated with a variant form of late infantile-onset neuronal ceroid lipofuscinoses (vLINCL). [provided by RefSeq, Oct 2008]
This gene encodes a ubiquitous integral membrane protein that contains a transporter domain and a major facilitator superfamily (MFS) domain. Other members of the major facilitator superfamily transport small solutes through chemiosmotic ion gradients. The substrate transported by this protein is unknown. The protein likely localizes to lysosomal membranes. Mutations in this gene are correlated with a variant form of late infantile-onset neuronal ceroid lipofuscinoses (vLINCL). [provided by RefSeq, Oct 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Ceroid Lipofuscinosis, Neuronal, 7 | 1 | 0.0 | 0.0 |
| MACULAR DYSTROPHY WITH CENTRAL CONE INVOLVEMENT | 1 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| hepatocellular carcinoma | 547 | 1.5e-07 |
| ovarian cancer | 8520 | 1.6e-07 |
| osteosarcoma | 7950 | 9.9e-06 |
| gastric cancer | 459 | 1.4e-04 |
| medulloblastoma, large-cell | 6241 | 4.2e-04 |
| group 4 medulloblastoma | 1855 | 5.5e-04 |
| progressive supranuclear palsy | 676 | 2.3e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Neuronal ceroid lipofuscinosis 7 | 2 | 0.0 | 5.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Neuronal ceroid lipofuscinosis | 28 | 5.888 | 2.9 |
| Neurodegenerative disease | 414 | 0.0 | 4.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Neurotic disorder | 9 | 4.5 | 2.3 |
| Visual pathway disease | 4 | 3.754 | 1.9 |
| Borderline personality disorder | 11 | 3.62 | 1.8 |
| Dysthymic Disorder | 17 | 3.341 | 1.7 |
| Delusional disorder | 13 | 3.324 | 1.7 |
| Schizophrenia | 1160 | 3.004 | 1.5 |
| Disease | Target Count |
|---|---|
| Ceroid lipofuscinosis neuronal 7 | 1 |
| Disease | log2 FC | p |
|---|---|---|
| gastric cancer | 1.600 | 1.4e-04 |
| group 4 medulloblastoma | 1.100 | 5.5e-04 |
| hepatocellular carcinoma | 1.200 | 1.5e-07 |
| medulloblastoma, large-cell | -1.300 | 4.2e-04 |
| osteosarcoma | -1.737 | 9.9e-06 |
| ovarian cancer | -1.400 | 1.6e-07 |
| progressive supranuclear palsy | -1.300 | 2.3e-02 |
MAGLRNESEQEPLLGDTPGSREWDILETEEHYKSRWRSIRILYLTMFLSSVGFSVVMMSIWPYLQKIDPT 1 - 70 ADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLYAYLHIPASHNKYYMLVARG 71 - 140 LLGIGAGNVAVVRSYTAGATSLQERTSSMANISMCQALGFILGPVFQTCFTFLGEKGVTWDVIKLQINMY 141 - 210 TTPVLLSAFLGILNIILILAILREHRVDDSGRQCKSINFEEASTDEAQVPQGNIDQVAVVAINVLFFVTL 211 - 280 FIFALFETIITPLTMDMYAWTQEQAVLYNGIILAALGVEAVVIFLGVKLLSKKIGERAILLGGLIVVWVG 281 - 350 FFILLPWGNQFPKIQWEDLHNNSIPNTTFGEIIIGLWKSPMEDDNERPTGCSIEQAWCLYTPVIHLAQFL 351 - 420 TSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPMFISQVYAHWGPRWAFSLVCG 421 - 490 IIVLTITLLGVVYKRLIALSVRYGRIQE 491 - 518 //
