| Tbio | Mitochondrial calcium uniporter regulator 1 |
Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion (PubMed:23178883, PubMed:26445506, PubMed:27184846, PubMed:26976564). Plays a direct role in uniporter-mediated calcium uptake via a direct interaction with MCU (PubMed:23178883). Probably involved in the assembly of the membrane components of the uniporter complex (uniplex) (PubMed:27184846).
Comments
| Disease | Target Count | P-value |
|---|---|---|
| malignant mesothelioma | 3232 | 1.5e-07 |
| medulloblastoma, large-cell | 6241 | 2.9e-04 |
| pancreatic carcinoma | 562 | 4.6e-04 |
| pancreatic cancer | 2398 | 4.6e-04 |
| psoriasis | 6694 | 6.0e-04 |
| invasive ductal carcinoma | 2951 | 7.8e-04 |
| group 4 medulloblastoma | 1855 | 1.1e-03 |
| lung cancer | 4740 | 3.1e-03 |
| ovarian cancer | 8520 | 4.3e-03 |
| Breast cancer | 3578 | 2.6e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Wolf-Hirschhorn syndrome | 32 | 3.869 | 1.9 |
| Disease | log2 FC | p |
|---|---|---|
| Breast cancer | 3.800 | 2.6e-02 |
| group 4 medulloblastoma | -1.100 | 1.1e-03 |
| invasive ductal carcinoma | -1.007 | 7.8e-04 |
| lung cancer | 1.300 | 3.1e-03 |
| malignant mesothelioma | 2.000 | 1.5e-07 |
| medulloblastoma, large-cell | -1.100 | 2.9e-04 |
| ovarian cancer | 1.600 | 4.3e-03 |
| pancreatic cancer | 1.600 | 4.6e-04 |
| pancreatic carcinoma | 1.600 | 4.6e-04 |
| psoriasis | 1.100 | 6.0e-04 |
MDCGSVGGQRTQRLPGRQRLLFLPVGLSGRPGGSETSARRCLSALSDGLGALRPRAPAARGGVSRASPLL 1 - 70 LLLLVPSPRLAAAAPRRQLGDWERSRLGYAAPPAGRSSAWRCSPGVAAAAGALPQYHGPAPALVSCRREL 71 - 140 SLSAGSLQLERKRRDFTSSGSRKLYFDTHALVCLLEDNGFATQQAEIIVSALVKILEANMDIVYKDMVTK 141 - 210 MQQEITFQQVMSQIANVKKDMIILEKSEFSALRAENEKIKLELHQLKQQVMDEVIKVRTDTKLDFNLEKS 211 - 280 RVKELYSLNEKKLLELRTEIVALHAQQDRALTQTDRKIETEVAGLKTMLESHKLDNIKYLAGSIFTCLTV 281 - 350 ALGFYRLWI 351 - 359 //
