| Tclin | Melanocyte-stimulating hormone receptor |
This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq, Jul 2008]
Comments
Property Summary
| Ligand Count | 76 |
| NCBI Gene PubMed Count | 308 |
| PubMed Score | 829.15 |
| PubTator Score | 591.83 |
| Disease | Target Count |
|---|---|
| Erythropoietic protoporphyria | 15 |
| Disease | Target Count | P-value |
|---|---|---|
| lung adenocarcinoma | 2716 | 2.6e-07 |
| inflammatory breast cancer | 286 | 3.8e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Oculocutaneous albinism | 29 | 4.662 | 2.3 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Skin cancer | 469 | 6.149 | 3.1 |
| Acute contagious conjunctivitis | 7 | 4.093 | 2.0 |
| Ocular melanoma | 4 | 3.47 | 1.7 |
| Squamous cell carcinoma | 129 | 3.007 | 1.5 |
| Disease | Target Count |
|---|---|
| Albinism, Oculocutaneous, Type 2 | 2 |
| Basal cell carcinoma | 54 |
| CMM1 | 5 |
| Melanocytic Nevus Syndrome, Congenital | 3 |
| familial melanoma | 10 |
| Disease | log2 FC | p |
|---|---|---|
| inflammatory breast cancer | 1.200 | 3.8e-02 |
| lung adenocarcinoma | 1.800 | 2.6e-07 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid EggNOG | ||
| Inparanoid EggNOG | ||
| Inparanoid EggNOG | ||
| Inparanoid EggNOG | ||
| Inparanoid EggNOG |
CHEMBL504349
pKi 7.00
CHEMBL448410
pKi 7.00
CHEMBL315258
pKi 7.04
CHEMBL88630
pKi 7.06
CHEMBL377620
pKi 7.07
CHEMBL380437
pKi 7.15
CHEMBL345234
pIC50 7.16
CHEMBL3601432
pIC50 7.17
CHEMBL443396
pKi 7.20
CHEMBL86573
pKi 7.20
CHEMBL328117
pKi 7.21
CHEMBL3601429
pEC50 7.24
CHEMBL327450
pKi 7.24
CHEMBL375440
pKi 7.26
CHEMBL407825
pKi 7.32
CHEMBL438118
pIC50 7.35
CHEMBL2070251
pKi 7.36
CHEMBL315356
pKi 7.37
CHEMBL329586
pKi 7.37
CHEMBL365278
pKi 7.38
MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVVATIAKNRNLH 1 - 70 SPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAV 71 - 140 DRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFIAYYDHVAVLLCLVVFFLAMLVLMAVLYVHM 141 - 210 LARACQHAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNF 211 - 280 NLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTCSW 281 - 317 //
