| Tbio | Melanoma-associated antigen E1 |
May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.
This gene encodes an alpha-dystrobrevin-associated MAGE (melanoma-associated antigen) protein, which is a member of the MAGE family. The protein contains a nuclear localization signal in the N-terminus, 30 12-amino acid repeats beginning at nt 60 with the consensus sequence ASEGPSTSVLPT, and two MAGE domains in the C-terminus. It may play a signaling role in brain, muscle, and peripheral nerve. This gene is located on X chromosome in a region containing loci linked to cognitive disability. [provided by RefSeq, Mar 2010]
This gene encodes an alpha-dystrobrevin-associated MAGE (melanoma-associated antigen) protein, which is a member of the MAGE family. The protein contains a nuclear localization signal in the N-terminus, 30 12-amino acid repeats beginning at nt 60 with the consensus sequence ASEGPSTSVLPT, and two MAGE domains in the C-terminus. It may play a signaling role in brain, muscle, and peripheral nerve. This gene is located on X chromosome in a region containing loci linked to cognitive disability. [provided by RefSeq, Mar 2010]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Liver Cirrhosis, Experimental | 769 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| glioblastoma | 5792 | 5.3e-09 |
| adult high grade glioma | 3801 | 6.7e-08 |
| atypical teratoid / rhabdoid tumor | 5112 | 9.6e-08 |
| Astrocytoma, Pilocytic | 3081 | 6.3e-06 |
| medulloblastoma, large-cell | 6241 | 1.1e-05 |
| group 3 medulloblastoma | 4104 | 2.9e-05 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 9.4e-04 |
| primitive neuroectodermal tumor | 3035 | 1.0e-03 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 2.0e-03 |
| astrocytic glioma | 2597 | 3.6e-03 |
| Pick disease | 1894 | 5.1e-03 |
| ependymoma | 4679 | 8.2e-03 |
| oligodendroglioma | 2850 | 1.8e-02 |
| subependymal giant cell astrocytoma | 2287 | 2.7e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -2.600 | 6.7e-08 |
| astrocytic glioma | -2.200 | 3.6e-03 |
| Astrocytoma, Pilocytic | -1.600 | 6.3e-06 |
| atypical teratoid / rhabdoid tumor | -1.600 | 9.6e-08 |
| ependymoma | -3.000 | 8.2e-03 |
| glioblastoma | -2.000 | 5.3e-09 |
| group 3 medulloblastoma | -2.600 | 2.9e-05 |
| intraductal papillary-mucinous adenoma (... | -1.800 | 2.0e-03 |
| intraductal papillary-mucinous carcinoma... | -2.200 | 9.4e-04 |
| medulloblastoma, large-cell | -2.200 | 1.1e-05 |
| oligodendroglioma | -1.700 | 1.8e-02 |
| Pick disease | -1.100 | 5.1e-03 |
| primitive neuroectodermal tumor | -1.300 | 1.0e-03 |
| subependymal giant cell astrocytoma | -2.526 | 2.7e-02 |
MSLVSQNSRRRRRRVAKATAHNSSWGEMQAPNAPGLPADVPGSDVPQGPSDSQILQGLCASEGPSTSVLP 1 - 70 TSAEGPSTFVPPTISEASSASGQPTISEGPGTSVLPTPSEGLSTSGPPTISKGLCTSVTLAASEGRNTSR 71 - 140 PPTSSEEPSTSVPPTASEVPSTSLPPTPGEGTSTSVPPTAYEGPSTSVVPTPDEGPSTSVLPTPGEGPGT 141 - 210 SVPLAATEGLSTSVQATPDEGPSTSVPPTATEGLSTPVPPTRDEGPSTSVPATPGEGPSTSVLPAASDGQ 211 - 280 SISLVPTRGKGSSTSVPPTATEGLSTSVQPTAGEGSSTSVPPTPGGGLSTSVPPTATEELSTSVPPTPGE 281 - 350 GPSTSVLPIPGEGLSTSVPPTASDGSDTSVPPTPGEGASTLVQPTAPDGPGSSVLPNPGEGPSTLFSSSA 351 - 420 SVDRNPSKCSLVLPSPRVTKASVDSDSEGPKGAEGPIEFEVLRDCESPNSISIMGLNTSRVAITLKPQDP 421 - 490 MEQNVAELLQFLLVKDQSKYPIRESEMREYIVKEYRNQFPEILRRAAAHLECIFRFELRELDPEAHTYIL 491 - 560 LNKLGPVPFEGLEESPNGPKMGLLMMILGQIFLNGNQAKEAEIWEMLWRMGVQRERRLSIFGNPKRLLSV 561 - 630 EFVWQRYLDYRPVTDCKPVEYEFFWGPRSHLETTKMKILKFMAKIYNKDPMDWPEKYNEALEEDAARAFA 631 - 700 EGWQALPHFRRPFFEEAAAEVPSPDSEVSSYSSKYAPHSWPESRLESKARKLVQLFLLMDSTKLPIPKKG 701 - 770 ILYYIGRECSKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYTLYNRREMEETEEIVDSPNRPGNNFLMQ 771 - 840 VLSFIFIMGNHARESAVWAFLRGLGVQAGRKHVITCRYLSQRYIDSLRVPDSDPVQYEFVWGPRARLETS 841 - 910 KMKALRYVARIHRKEPQDWPQQYREAMEDEANRADVGHRQIFVHNFR 911 - 957 //
