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Tdark Ly6/PLAUR domain-containing protein 6B

Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro acts on nAChRs in a subtype- and stoichiometry-dependent manner. Modulates specifally alpha-3(3):beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2):alpha-5:beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn-398 but not its wild-type sequence.

 Comments

Property Summary

NCBI Gene PubMed Count 5
PubMed Score 2.77
PubTator Score 1.98

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count Z-score Confidence
Nicotine dependence 54 4.326 2.2

Expression

  Differential Expression (11)

Disease log2 FC p
active Crohn's disease 1.072 2.4e-02
chronic rhinosinusitis -1.045 4.7e-03
fibroadenoma 1.200 7.2e-03
group 3 medulloblastoma -1.400 5.3e-03
Hydrolethalus syndrome 2.028 4.5e-02
interstitial cystitis -1.700 1.5e-02
intraductal papillary-mucinous adenoma (... 2.200 2.9e-05
non-small cell lung cancer 1.852 7.3e-14
ovarian cancer 2.200 1.9e-05
pituitary cancer 1.900 1.8e-03
psoriasis -1.200 2.2e-52

Synonym

Accession Q8NI32 D3DP90 Q53TK0 Q7Z747 Q8IXK7
Symbols CT116
LYPD7

Gene

LYPD6B

  Ortholog (14)

Species Source Disease
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA
Inparanoid EggNOG
OMA EggNOG

 UniProt Keyword (10)

 GO Function (1)

 GO Component (3)

 GO Process (1)

 Compartment GO Term (10)

 IMPC Phenotype (3)

 MGI Phenotype (4)

 HCA RNA Cell Line (45)

See all...

Pathway (3)

Protein-protein Interaction (9)

UBR4   IDE   UBR1   AMY1C   ARMC8   UBR2   PSME4   PLXDC2   KCMF1  

Gene RIF (2)

AA Sequence 

MLYKSSDRPAHKVSMLLLCHALAIAVVQIVIFSESWAFAKNINFYNVRPPLDPTPFPNSFKCFTCENAGD      1 - 70
NYNCNRWAEDKWCPQNTQYCLTVHHFTSHGRSTSITKKCASRSECHFVGCHHSRDSEHTECRSCCEGMIC     71 - 140
NVELPTNHTNAVFAVMHAQRTSGSSAPTLYLPVLAWVFVLPLL                               141 - 183
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Text Mined References (7)

PMID Year Title