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Tdark Leucine rich adaptor protein 1

Acts as an activator of the canonical NF-kappa-B pathway and drive the production of proinflammatory cytokines. Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway (PubMed:21048106). In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Activates CDC42BPA/CDC42BPB and targets it to actomyosin through its interaction with MYO18A, leading to MYL9/MLC2 phosphorylation and MYH9/MYH10-dependent actomyosin assembly in the lamella (By similarity).

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Property Summary

NCBI Gene PubMed Count 9
PubMed Score 2.39
PubTator Score 2.81

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (1)

Disease Target Count P-value
osteosarcoma 7950 9.4e-06

Expression

  Differential Expression (1)

Disease log2 FC p
osteosarcoma 1.230 9.4e-06

Synonym

Accession Q96LR2
Symbols LRP35A
LRAP35a
C1orf190

Gene

LURAP1

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (6)

 GO Component (2)

 GO Process (4)

 Compartment GO Term (10)

 HCA RNA Cell Line (55)

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Gene RIF (1)

AA Sequence 

MEGTVESQTPDLRDVEGKVGRKTPEGLLRGLRGECELGTSGALLLPGASSTGHDLGDKIMALKMELAYLR      1 - 70
AIDVKILQQLVTLNEGIEAVRWLLEERGTLTSHCSSLTSSQYSLTGGSPGRSRRGSWDSLPDTSTTDRLD     71 - 140
SVSIGSFLDTVAPSELDEQGPPGAPRSEMDWAKVIAGGERARTEVDVAATRLGSLRAVWKPPGERLQGGP    141 - 210
PESPEDESAKLGFEAHWFWEQCQDDVTFL                                             211 - 239
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Text Mined References (10)

PMID Year Title