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Tbio Tumor necrosis factor receptor superfamily member 3

Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.

This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]

 Comments

Property Summary

NCBI Gene PubMed Count 79
PubMed Score 249.86
PubTator Score 147.55

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (5)

Disease Target Count Z-score Confidence
Malaria 160 0.0 0.0
Disease Target Count P-value
ovarian cancer 8520 4.7e-07
tuberculosis 2010 3.3e-06
psoriasis 6694 8.5e-05
subependymal giant cell astrocytoma 2287 2.4e-03
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.6
Disease Target Count Z-score Confidence
Ankylosing spondylitis 140 0.0 3.0
Disease Target Count Z-score Confidence
Cancer 2499 3.031 1.5

Expression

  Differential Expression (4)

Disease log2 FC p
ovarian cancer 1.300 4.7e-07
psoriasis 1.600 8.5e-05
subependymal giant cell astrocytoma 1.142 2.4e-03
tuberculosis 1.200 3.3e-06

Synonym

Accession P36941 B7Z1D2 D3DUR2 F5GXE7
Symbols CD18
TNFCR
TNFR3
D12S370
TNFR-RP
TNFRSF3
TNFR2-RP
LT-BETA-R
TNF-R-III

Gene

LTBR

  Ortholog (9)

Species Source Disease
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG

 UniProt Keyword (16)

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 GO Function (3)

 GO Component (2)

 GO Process (14)

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 Compartment GO Term (27)

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 MGI Phenotype (8)

 GWAS Trait (7)

 HCA RNA Cell Line (54)

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 CSPA Cell Line (26)

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Pathway (10)

Protein-protein Interaction (57)

UBB   ZNF865   BLZF1   CCDC93   SPATS2   CEP131   HGS   ODF2   PRC1   ZNF724   BIRC2   TAOK2   PLK1   TRAF3   CEP78   ZWINT   POM121   MKI67   ZC3H3   CEP120   SPATS2L   MAP7D1   TRAF1   HDAC5   TRAF2   CEP95   SDCBP   MAP4K4   TNIK   POLRMT   IQCB1   VAPA   SLTM   CCDC121   IKBKG   CD320   TBC1D31   CCDC112   RNF31   RNF166   SHARPIN   IFT81   CCHCR1   THAP3   TCHP   CCDC113   SPC25   TRIM4   ARHGEF18   CCDC77   CISD2   RNF114   SKI   RBCK1   TNFRSF10B   NBR1   TIGD5  

PDB (2)

Gene RIF (44)

AA Sequence 

MLLPWATSAPGLAWGPLVLGLFGLLAASQPQAVPPYASENQTCRDQEKEYYEPQHRICCSRCPPGTYVSA      1 - 70
KCSRIRDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEEIAPCTSKRKTQCRCQPGMFCAAWALECT     71 - 140
HCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHFQNTSSPSARCQPHTRCENQGLVEAAPGTAQSDTTC    141 - 210
KNPLEPLPPEMSGTMLMLAVLLPLAFFLLLATVFSCIWKSHPSLCRKLGSLLKRRPQGEGPNPVAGSWEP    211 - 280
PKAHPYFPDLVQPLLPISGDVSPVSTGLPAAPVLEAGVPQQQSPLDLTREPQLEPGEQSQVAHGTNGIHV    281 - 350
TGGSMTITGNIYIYNGPVLGGPPGPGDLPATPEPPYPIPEEGDPGPPGLSTPHQEDGKAWHLAETEHCGA    351 - 420
TPSNRGPRNQFITHD                                                           421 - 435
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Text Mined References (82)

PMID Year Title