Tbio | Tumor necrosis factor receptor superfamily member 3 |
Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.
This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]
This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]
Comments
Disease | Target Count | P-value |
---|---|---|
ovarian cancer | 8520 | 4.7e-07 |
tuberculosis | 2010 | 3.3e-06 |
psoriasis | 6694 | 8.5e-05 |
subependymal giant cell astrocytoma | 2287 | 2.4e-03 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Ankylosing spondylitis | 140 | 0.0 | 3.0 |
Disease | log2 FC | p |
---|---|---|
ovarian cancer | 1.300 | 4.7e-07 |
psoriasis | 1.600 | 8.5e-05 |
subependymal giant cell astrocytoma | 1.142 | 2.4e-03 |
tuberculosis | 1.200 | 3.3e-06 |
Species | Source | Disease |
---|---|---|
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG |
UBB
ZNF865
BLZF1
CCDC93
SPATS2
CEP131
HGS
ODF2
PRC1
ZNF724
BIRC2
TAOK2
PLK1
TRAF3
CEP78
ZWINT
POM121
MKI67
ZC3H3
CEP120
SPATS2L
MAP7D1
TRAF1
HDAC5
TRAF2
CEP95
SDCBP
MAP4K4
TNIK
POLRMT
IQCB1
VAPA
SLTM
CCDC121
IKBKG
CD320
TBC1D31
CCDC112
RNF31
RNF166
SHARPIN
IFT81
CCHCR1
THAP3
TCHP
CCDC113
SPC25
TRIM4
ARHGEF18
CCDC77
CISD2
RNF114
SKI
RBCK1
TNFRSF10B
NBR1
TIGD5
MLLPWATSAPGLAWGPLVLGLFGLLAASQPQAVPPYASENQTCRDQEKEYYEPQHRICCSRCPPGTYVSA 1 - 70 KCSRIRDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEEIAPCTSKRKTQCRCQPGMFCAAWALECT 71 - 140 HCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHFQNTSSPSARCQPHTRCENQGLVEAAPGTAQSDTTC 141 - 210 KNPLEPLPPEMSGTMLMLAVLLPLAFFLLLATVFSCIWKSHPSLCRKLGSLLKRRPQGEGPNPVAGSWEP 211 - 280 PKAHPYFPDLVQPLLPISGDVSPVSTGLPAAPVLEAGVPQQQSPLDLTREPQLEPGEQSQVAHGTNGIHV 281 - 350 TGGSMTITGNIYIYNGPVLGGPPGPGDLPATPEPPYPIPEEGDPGPPGLSTPHQEDGKAWHLAETEHCGA 351 - 420 TPSNRGPRNQFITHD 421 - 435 //