| Tbio | Leucine-rich repeat-containing protein 59 |
Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| lung adenocarcinoma | 2716 | 3.8e-12 |
| ovarian cancer | 8520 | 1.4e-06 |
| Breast cancer | 3578 | 4.1e-05 |
| medulloblastoma, large-cell | 6241 | 1.4e-04 |
| breast carcinoma | 1638 | 1.5e-04 |
| invasive ductal carcinoma | 2951 | 7.2e-04 |
| pancreatic cancer | 2398 | 8.1e-04 |
| primary pancreatic ductal adenocarcinoma | 1109 | 1.5e-03 |
| psoriasis | 6694 | 1.6e-03 |
| Multiple myeloma | 1332 | 5.2e-03 |
| glioblastoma | 5792 | 5.9e-03 |
| non diabetic and post-ischemic heart failure | 200 | 7.9e-03 |
| lung cancer | 4740 | 1.2e-02 |
| Disease | log2 FC | p |
|---|---|---|
| Breast cancer | 1.100 | 4.1e-05 |
| breast carcinoma | 1.600 | 1.5e-04 |
| glioblastoma | 1.300 | 5.9e-03 |
| invasive ductal carcinoma | 1.900 | 7.2e-04 |
| lung adenocarcinoma | 1.300 | 3.8e-12 |
| lung cancer | 1.200 | 1.2e-02 |
| medulloblastoma, large-cell | 1.200 | 1.4e-04 |
| Multiple myeloma | 1.210 | 5.2e-03 |
| non diabetic and post-ischemic heart fai... | -1.200 | 7.9e-03 |
| ovarian cancer | 3.200 | 1.4e-06 |
| pancreatic cancer | -1.800 | 8.1e-04 |
| primary pancreatic ductal adenocarcinoma | -1.537 | 1.5e-03 |
| psoriasis | 1.100 | 1.6e-03 |
MTKAGSKGGNLRDKLDGNELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLS 1 - 70 KNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAGDCLDEKQCKQC 71 - 140 ANKVLQHMKAVQADQERERQRRLEVEREAEKKREAKQRAKEAQERELRKREKAEEKERRRKEYDALKAAK 141 - 210 REQEKKPKKEANQAPKSKSGSRPRKPPPRKHTRSWAVLKLLLLLLLFGVAGGLVACRVTELQQQPLCTSV 211 - 280 NTIYDNAVQGLRRHEILQWVLQTDSQQ 281 - 307 //
