Property Summary

NCBI Gene PubMed Count 17
PubMed Score 14.45
PubTator Score 10.62

Knowledge Summary


No data available


  Differential Expression (25)

Gene RIF (7)

25829251 MiR-101 decreased the expression of LMO3 by reversing the methylation status of the LMO3 promoter and by inhibiting the presence of the methylation-related histones H3K4me2 and H3K27me3 and increasing the presence of H3K9me3 and H4K20me3 on the promoter.
23823477 LMO3 as a regulator of human adipogenesis and could contribute a mechanism resulting in visceral-fat accumulation in obesity due to excess glucocorticoids.
23322301 suggest that LMO3 is a transcriptional signal transducer in NKX2-1-amplified lung adenocarcinomas
22011669 We confirmed that the expression of LMO3 in squamous cell carcinoma is regulated by DNA methylation of its specific promoter region.
21573214 The present results suggest that a transcriptional complex of LMO3 and HEN2 may contribute to the genesis and malignant phenotype of neuroblastoma by inhibiting HES1 which suppresses the transactivation of Mash1.
19995558 LMO3 acts as a co-repressor of p53, suppressing p53-dependent transcriptional regulation without inhibition of its DNA-binding activity.
15930276 The deregulated expression of neuronal-specific LMO3 and HEN2 contributes to the genesis and progression of human neuroblastoma in a lineage-specific manner.

AA Sequence

APQVR                                                                     141 - 145

Text Mined References (18)

PMID Year Title
25829251 2015 MiR-101 reverses the hypomethylation of the LMO3 promoter in glioma cells.
25416956 2014 A proteome-scale map of the human interactome network.
24379077 2014 LIM-domain-only proteins: multifunctional nuclear transcription coregulators that interacts with diverse proteins.
23823477 2013 Human but not mouse adipogenesis is critically dependent on LMO3.
23322301 2013 Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target.
22011669 2012 Genome-wide analysis of DNA methylation and the gene expression change in lung cancer.
21573214 2011 Oncogenic LMO3 collaborates with HEN2 to enhance neuroblastoma cell growth through transactivation of Mash1.
19995558 2010 LMO3 interacts with p53 and inhibits its transcriptional activity.
16713569 2006 A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
16541075 2006 The finished DNA sequence of human chromosome 12.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
16189514 2005 Towards a proteome-scale map of the human protein-protein interaction network.
15930276 2005 LMO3 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11489251 2001 Identification of dopamine responsive mRNAs in glial cells by suppression subtractive hybridization.
1507224 1992 The rhombotin gene family encode related LIM-domain proteins whose differing expression suggests multiple roles in mouse development.