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  6. LIM/homeobox protein Lhx9

Tdark LIM/homeobox protein Lhx9

Involved in gonadal development.

This gene encodes a member of the LIM homeobox gene family of developmentally expressed transcription factors. The encoded protein contains a homeodomain and two cysteine-rich zinc-binding LIM domains involved in protein-protein interactions. The protein is highly similar to a mouse protein that causes gonadal agenesis when inactivated, suggesting a role in gonadal development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

 Comments

Property Summary

NCBI Gene PubMed Count 10
PubMed Score 25.94
PubTator Score 9.35

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count Z-score Confidence
Frasier syndrome 7 3.741 1.9
Narcolepsy 69 3.139 1.6

Expression

  Differential Expression (5)

Disease log2 FC p
osteosarcoma -1.267 1.6e-06
atypical teratoid / rhabdoid tumor 2.300 2.5e-02
medulloblastoma, large-cell 3.300 7.9e-03
group 3 medulloblastoma 2.800 1.2e-02
ovarian cancer -5.500 4.1e-24

Synonym

Accession Q9NQ69 Q5VUE2 Q5VUE3 Q5VUE6 Q86UH2 Q9BYU6 Q9NQ70 LIM homeobox protein 9
Symbols

Gene

LHX9

PANTHER Protein Class (3)

PDB

2DMQ  

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (11)

See all...

 GO Function (3)

 GO Component (1)

 GO Process (6)

 Compartment GO Term (10)

 MGI Phenotype (6)

 HCA RNA Cell Line (40)

See all...

Pathway (1)

Protein-protein Interaction (4)

PARP2   ZHX1   SSBP3   LDB1  

Gene RIF (2)

PMID Text
19568415 LHX9 gene is frequently silenced in pediatric malignant astrocytomas
19545367 Lhx9 and Lhx1 serve as a binary switch in controlling the rostral versus caudal longitudinal turning of the caudal commissural axons. Lhx1 determines caudal turning and Lhx9 triggers rostral turning.

AA Sequence 

MEIVGCRAEDNSCPFRPPAMLFHGISGGHIQGIMEEMERRSKTEARLAKGAQLNGRDAGMPPLSPEKPAL      1 - 70
CAGCGGKISDRYYLLAVDKQWHLRCLKCCECKLALESELTCFAKDGSIYCKEDYYRRFSVQRCARCHLGI     71 - 140
SASEMVMRARDSVYHLSCFTCSTCNKTLTTGDHFGMKDSLVYCRAHFETLLQGEYPPQLSYTELAAKSGG    141 - 210
LALPYFNGTGTVQKGRPRKRKSPALGVDIVNYNSGCNENEADHLDRDQQPYPPSQKTKRMRTSFKHHQLR    211 - 280
TMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENGGVDKADGTSLPAPPSADS    281 - 350
GALTPPGTATTLTDLTNPTITVVTSVTSNMDSHESGSPSQTTLTNLF                           351 - 397
//

Text Mined References (11)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
19568415 2009 Aberrant methylation and reduced expression of LHX9 in malignant gliomas of childhood.
19545367 2009 Transcriptional control of axonal guidance and sorting in dorsal interneurons by the Lim-HD proteins Lhx9 and Lhx1.
16710414 2006 The DNA sequence and biological annotation of human chromosome 1.
15761153 2005 High-throughput mapping of a dynamic signaling network in mammalian cells.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11397841 2001 Absence of mutations involving the LIM homeobox domain gene LHX9 in 46,XY gonadal agenesis and dysgenesis.
9880598 1999 Lhx9: a novel LIM-homeodomain gene expressed in the developing forebrain.
7566098 1995 Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.