| Tbio | LIM/homeobox protein Lhx9 |
Involved in gonadal development.
This gene encodes a member of the LIM homeobox gene family of developmentally expressed transcription factors. The encoded protein contains a homeodomain and two cysteine-rich zinc-binding LIM domains involved in protein-protein interactions. The protein is highly similar to a mouse protein that causes gonadal agenesis when inactivated, suggesting a role in gonadal development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
This gene encodes a member of the LIM homeobox gene family of developmentally expressed transcription factors. The encoded protein contains a homeodomain and two cysteine-rich zinc-binding LIM domains involved in protein-protein interactions. The protein is highly similar to a mouse protein that causes gonadal agenesis when inactivated, suggesting a role in gonadal development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 4.1e-24 |
| osteosarcoma | 7950 | 1.6e-06 |
| group 3 medulloblastoma | 4104 | 1.2e-02 |
| medulloblastoma, large-cell | 6241 | 2.2e-02 |
| atypical teratoid / rhabdoid tumor | 5112 | 4.4e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Frasier syndrome | 7 | 3.742 | 1.9 |
| Narcolepsy | 72 | 3.109 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| atypical teratoid / rhabdoid tumor | 1.100 | 4.4e-02 |
| group 3 medulloblastoma | 2.800 | 1.2e-02 |
| medulloblastoma, large-cell | 1.500 | 2.2e-02 |
| osteosarcoma | -1.267 | 1.6e-06 |
| ovarian cancer | -5.500 | 4.1e-24 |
MEIVGCRAEDNSCPFRPPAMLFHGISGGHIQGIMEEMERRSKTEARLAKGAQLNGRDAGMPPLSPEKPAL 1 - 70 CAGCGGKISDRYYLLAVDKQWHLRCLKCCECKLALESELTCFAKDGSIYCKEDYYRRFSVQRCARCHLGI 71 - 140 SASEMVMRARDSVYHLSCFTCSTCNKTLTTGDHFGMKDSLVYCRAHFETLLQGEYPPQLSYTELAAKSGG 141 - 210 LALPYFNGTGTVQKGRPRKRKSPALGVDIVNYNSGCNENEADHLDRDQQPYPPSQKTKRMRTSFKHHQLR 211 - 280 TMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENGGVDKADGTSLPAPPSADS 281 - 350 GALTPPGTATTLTDLTNPTITVVTSVTSNMDSHESGSPSQTTLTNLF 351 - 397 //
