Tchem L-lactate dehydrogenase A chain

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The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008]

Comments

Property Summary

Ligand Count	80
NCBI Gene PubMed Count	143
PubMed Score	1030.51

PubTator Score	280.45

Knowledge Summary

Patent

No data available

TINX Plot

Disease (8)

Disease	Target Count	Z-score	Confidence
Myocardial Infarction	151	4.493	2.2
Myoglobinuria	15	3.197	1.6
Adenocarcinoma of lung	142	0.0	0.0
Cardiomyopathies	110	0.0	0.0
Disease Models, Animal	155	0.0	0.0
Lactate dehydrogenase deficiency type A	1	0.0	0.0

Disease	Target Count
Autosomal recessive predisposition	1442
Bipolar Disorder	666
Creatine phosphokinase serum increased	110
Elevated creatine kinase	110
Impaired exercise tolerance	42
Increased serum lactate	60
Increased serum pyruvate	9
Kidney Failure	111
Major Depressive Disorder	301
Mental Depression	333
Mood Disorders	184
Muscle Cramp	55
Muscle Rigidity	49
Muscular stiffness	12
Myalgia	54
Renal Insufficiency	90
Renal failure in adulthood	76
Rhabdomyolysis	15
Unipolar Depression	250

Disease	Target Count	P-value
diabetes mellitus	1728	4.8e-03

Disease	Target Count	Z-score	Confidence
Carcinoma	11493	0.0	0.8
Kidney cancer	2613	0.0	0.5

Disease	Target Count	Z-score	Confidence
Amyloidosis	67	0.0	3.0

Disease	Target Count	Z-score	Confidence
Glycogen storage disease	39	0.0	4.0

Disease	Target Count	Z-score	Confidence
Cancer	2499	4.813	2.4

Disease	Target Count
Glycogen Storage Disease 11	1

Differential Expression (1)

Disease	log2 FC	p
diabetes mellitus	-1.200	4.8e-03

Cells - EBV-transformed lymphocytes 18,186

Cells - Transformed fibroblasts 17,577

Artery - Aorta 17,896

Artery - Tibial 17,631

Skin - Sun Exposed (Lower leg) 17,968

Skin - Not Sun Exposed (Suprapubic) 18,081

Artery - Coronary 17,949

Adipose - Subcutaneous 18,110

Muscle - Skeletal 17,778

Small Intestine - Terminal Ileum 17,954

Lung 18,057

Adipose - Visceral (Omentum) 17,937

Breast - Mammary Tissue 18,103

Esophagus - Mucosa 18,076

Nerve - Tibial 18,007

Whole Blood 17,439

Colon - Transverse 17,825

Esophagus - Muscularis 18,017

Vagina 17,834

Minor Salivary Gland 18,005

Thyroid 18,024

Esophagus - Gastroesophageal Junction 18,000

Colon - Sigmoid 18,089

Brain - Frontal Cortex (BA9) 18,069

Adrenal Gland 18,071

Stomach 17,879

Spleen 17,614

Heart - Atrial Appendage 17,896

Brain - Cerebellar Hemisphere 18,015

Prostate 18,213

Testis 18,518

Liver 18,071

Brain - Cerebellum 17,983

Brain - Cortex 18,039

Brain - Hypothalamus 18,169

Uterus 17,618

Brain - Anterior cingulate cortex (BA24) 17,989

Brain - Nucleus accumbens (basal ganglia... 18,024

Brain - Caudate (basal ganglia) 18,001

Ovary 17,971

Brain - Substantia nigra 17,981

Brain - Spinal cord (cervical c-1) 17,973

Brain - Amygdala 18,006

Brain - Putamen (basal ganglia) 17,863

Pituitary 18,147

Brain - Hippocampus 18,011

Kidney - Cortex 17,329

Pancreas 18,123

Heart - Left Ventricle 18,006

Adult Retina 10,115

Fetal Heart 9,228

Adult Liver 9,113

Fetal Liver 8,402

Adult Adrenal 8,475

Platelets 6,131

Adult Kidney 6,723

Adult Esophagus 4,936

Adult Frontal Cortex 9,048

Fetal Brain 7,866

CD8 Cells 9,840

Fetal Testis 7,955

CD4 Cells 7,773

Fetal Ovary 9,118

Adult Ovary 10,192

Adult Spinal Cord 7,594

Adult Urinary Bladder 7,592

NK Cells 8,475

Fetal Gut 8,640

Adult Gallbladder 7,612

Adult Testis 10,836

B Cells 9,086

Adult Colon 7,915

Adult Prostate 8,952

Adult Pancreas 9,168

Monocytes 7,422

Adult Lung 6,663

Adult Rectum 8,022

Adult Heart 6,506

Adrenal gland

Blood platelet

Brain

Colon

Frontal lobe

Gall bladder

Gut

Heart

Kidney

Liver

Lung

B-lymphocyte

Monocyte

Natural killer cell

Esophagus

Ovary

Pancreas

Placenta 6,083

Prostate gland

Rectum

Retina

Spinal cord

Testis

Urinary bladder

BTO:0004410

BTO:0005453

adipose tissue 15,837

adrenal gland 15,963

appendix 16,247

bone marrow 14,571

breast 16,063

cerebral cortex 16,630

cervix, uterine 15,871

colon 15,959

duodenum 15,975

endometrium 16,349

epididymis 15,863

esophagus 15,898

fallopian tube 16,245

gallbladder 16,333

heart muscle 14,972

kidney 15,917

liver 14,587

lung 16,312

lymph node 15,833

ovary 15,408

pancreas 14,070

parathyroid gland 14,769

placenta 15,937

prostate 16,460

rectum 15,705

salivary gland 14,981

seminal vesicle 15,918

skeletal muscle 14,011

skin 16,206

small intestine 16,154

smooth muscle 15,857

spleen 15,972

stomach 16,099

testis 17,936

thyroid gland 15,959

tonsil 15,400

urinary bladder 15,814

Liver and Pancreas 16,750

Digestive Tract 17,369

Urinary Tract 16,678

Endocrine System 18,159

Blood and immune system 16,909

Respiratory system 16,393

Female tissues 17,400

Male tissues 17,142

Skin and soft tissues 17,230

Nervous System 16,725

Cardiovascular System 15,192

Gastric adenocarcinoma cell 25

Renal cell carcinoma cell 72

Bone marrow 636

Cervical carcinoma cell 4,944

Erythroleukemia cell 4,300

Liver 5,008

Umbilical cord 9

B-cell lymphoma cell 130

T-cell chronic lymphocytic leukemia cell 2,346

See source...

Muscle 1,170

Heart 914

Blood 1,962

Liver 1,045

Somatic cell 102

Germ cell 264

Semen 285

Bradyzoite 9

See source...

Synonym

Accession	P00338 B4DKQ2 B7Z5E3 D3DQY3 F8W819 Q53G53 Q6IBM7 Q6ZNV1 Q9UDE8 Q9UDE9 LDH-A
Symbols	LDHM GSD11 PIG19 HEL-S-133P

Gene

LDHA

PANTHER Protein Class (2)

oxidoreductase 319

dehydrogenase 173

Ortholog (11)

Species	Source	Disease
Chimp 14,140	Inparanoid OMA EggNOG
Mouse 16,570	Inparanoid EggNOG
Macaque 12,761	Inparanoid OMA EggNOG
Dog 15,073	Inparanoid OMA EggNOG
Rat 15,117	Inparanoid OMA
Cow 15,320	Inparanoid OMA EggNOG
Horse 14,252	Inparanoid OMA EggNOG
Opossum 12,230	OMA EggNOG
Pig 10,168	Inparanoid OMA EggNOG
Xenopus 10,468	OMA EggNOG
Chicken 7,827	Inparanoid OMA

UniProt Keyword (15)

Complete proteome 20,231

Polymorphism 12,194

Reference proteome 20,231

Alternative splicing 10,528

Cytoplasm 4,952

Disease mutation 2,804

Isopeptide bond 1,739

Phosphoprotein 8,216

Ubl conjugation 2,439

Acetylation 3,409

See all...

GO Function (5)

identical protein binding 1,084

kinase binding 92

cadherin binding 277

NAD binding 40

L-lactate dehydrogenase activity 5

GO Component (4)

nucleus 5,097

cytosol 4,834

membrane 1,917

extracellular exosome 2,767

GO Process (14)

positive regulation of apoptotic process 320

response to cAMP 47

response to hydrogen peroxide 49

response to nutrient 71

response to drug 303

glycolytic process 26

response to glucose 66

response to hypoxia 166

pyruvate metabolic process 22

NAD metabolic process 16

See all...

Compartment GO Term (24)

Catalytic complex 1,642

Cell 16,178

Cell part 16,177

Cytoplasm 10,983

Cytoplasmic part 9,247

Cytosol 6,686

Glucose transporter complex 61

Glutamate dehydrogenase complex 37

Intracellular 14,109

Intracellular membrane-bounded organelle 10,341

Intracellular organelle 12,025

Intracellular part 13,972

Macromolecular complex 5,475

Mitochondrion 1,576

Organelle 12,238

See all...

mortality-aging 5,018

liver-biliary system phenotype 1,300

respiratory system phenotype 1,390

immune system phenotype 3,461

neoplasm 975

normal phenotype 1,999

GWAS Trait (1)

Amyloid A serum levels 5

HCA RNA Cell Line (56)

A-431 16,131

A549 15,174

AF22 16,160

AN3-CA 15,648

ASC TERT1 14,842

BEWO 16,726

BJ 15,448

BJ hTERT+ 15,353

BJ hTERT+ SV40 Large T+ 15,609

BJ hTERT+ SV40 Large T+ RasG12V 15,493

See all...

Pathway (48)

Metabolic pathways 1,263

Central carbon metabolism in cancer 65

Glycolysis / Gluconeogenesis 68

Glucagon signaling pathway 105

HIF-1 signaling pathway 100

Pyruvate metabolism 39

Cysteine and methionine metabolism 45

Propanoate metabolism 32

http://pathwaycommons.org/pc2/Pathway_96... 5

http://pathwaycommons.org/pc2/Pathway_3a... 4

See all...

Protein-protein Interaction (2)

LDHB LDHC

PDB (18)

...
More...

Ligand (80)

CHEMBL127326
pKi 6.00

CHEMBL3765137
pKi 6.00

CHEMBL127327
pKi 6.00

CHEMBL3318525
pIC50 6.00

CHEMBL3318469
pIC50 6.06

CHEMBL3318412
pIC50 6.06

CHEMBL3318522
pIC50 6.06

CHEMBL2316888
pKd 6.07

CHEMBL3318534
pIC50 6.08

CHEMBL2382402
pIC50 6.13

CHEMBL2382403
pIC50 6.15

CHEMBL341463
pKi 6.16

CHEMBL2382404
pIC50 6.19

CHEMBL3581188
pIC50 6.19

CHEMBL3318536
pIC50 6.19

CHEMBL110030
pKi 6.22

CHEMBL3359440
pIC50 6.22

CHEMBL3318524
pIC50 6.24

CHEMBL2430727
pIC50 6.30

CHEMBL3318529
pIC50 6.30

See all 80 ligands...

Gene RIF (107)

AA Sequence

MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSL      1 - 70
FLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPV     71 - 140
DILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVS    141 - 210
LKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGL    211 - 280
YGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF                      281 - 332
//

Text Mined References (155)

Summary
Details

	PMID	Year	Title

Tchem L-lactate dehydrogenase A chain Add to cart View Collections Empty Collection

Property Summary

Knowledge Summary

Patent

No data available

TINX Plot

Disease (8)

Expression

Differential Expression (1)

Synonym

Gene

PANTHER Protein Class (2)

Ortholog (11)

UniProt Keyword (15)

GO Function (5)

GO Component (4)

GO Process (14)

Compartment GO Term (24)

IMPC Phenotype (6)

OMIM Phenotype (1)

MGI Phenotype (10)

GWAS Trait (1)

HCA RNA Cell Line (56)

Pathway (48)

Protein-protein Interaction (2)

PDB (18)

Ligand (80)

Gene RIF (107)

AA Sequence

Text Mined References (155)

Tchem L-lactate dehydrogenase A chain

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