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Tchem L-lactate dehydrogenase A chain

The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008]

 Comments

Property Summary

Ligand Count 80
NCBI Gene PubMed Count 143
PubMed Score 1030.51
PubTator Score 280.45

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (8)

Disease Target Count P-value
diabetes mellitus 1728 4.8e-03
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.8
Kidney cancer 2613 0.0 0.5
Disease Target Count Z-score Confidence
Amyloidosis 67 0.0 3.0
Disease Target Count Z-score Confidence
Glycogen storage disease 39 0.0 4.0
Disease Target Count Z-score Confidence
Cancer 2499 4.813 2.4
Disease Target Count
Glycogen Storage Disease 11 1

Expression

  Differential Expression (1)

Disease log2 FC p
diabetes mellitus -1.200 4.8e-03

Synonym

Accession P00338 B4DKQ2 B7Z5E3 D3DQY3 F8W819 Q53G53 Q6IBM7 Q6ZNV1 Q9UDE8 Q9UDE9 LDH-A
Symbols LDHM
GSD11
PIG19
HEL-S-133P

Gene

LDHA

PANTHER Protein Class (2)

PDB

1I10   4AJP   4JNK   4L4R   4L4S   4M49   4OJN   4OKN   4QO7   4QO8   4QSM   4QT0   4R68   4R69   4RLS   4ZVV   5IXS   5IXY  

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG Inparanoid

 UniProt Keyword (15)

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 GO Function (5)

 GO Component (4)

 GO Process (14)

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 Compartment GO Term (24)

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 IMPC Phenotype (6)

 OMIM Phenotype (1)

 MGI Phenotype (10)

 GWAS Trait (1)

 HCA RNA Cell Line (56)

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Pathway (48)

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Protein-protein Interaction (2)

LDHB   LDHC  

Ligand (80)

Structure of CHEMBL127326

CHEMBL127326
pKi 6.00

Structure of CHEMBL3765137

CHEMBL3765137
pKi 6.00

Structure of CHEMBL127327

CHEMBL127327
pKi 6.00

Structure of CHEMBL3318525

CHEMBL3318525
pIC50 6.00

Structure of CHEMBL3318469

CHEMBL3318469
pIC50 6.06

Structure of CHEMBL3318412

CHEMBL3318412
pIC50 6.06

Structure of CHEMBL3318522

CHEMBL3318522
pIC50 6.06

Structure of CHEMBL2316888

CHEMBL2316888
pKd 6.07

Structure of CHEMBL3318534

CHEMBL3318534
pIC50 6.08

Structure of CHEMBL2382402

CHEMBL2382402
pIC50 6.13

Structure of CHEMBL2382403

CHEMBL2382403
pIC50 6.15

Structure of CHEMBL341463

CHEMBL341463
pKi 6.16

Structure of CHEMBL2382404

CHEMBL2382404
pIC50 6.19

Structure of CHEMBL3581188

CHEMBL3581188
pIC50 6.19

Structure of CHEMBL3318536

CHEMBL3318536
pIC50 6.19

Structure of CHEMBL110030

CHEMBL110030
pKi 6.22

Structure of CHEMBL3359440

CHEMBL3359440
pIC50 6.22

Structure of CHEMBL3318524

CHEMBL3318524
pIC50 6.24

Structure of CHEMBL2430727

CHEMBL2430727
pIC50 6.30

Structure of CHEMBL3318529

CHEMBL3318529
pIC50 6.30

Gene RIF (107)

AA Sequence 

MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSL      1 - 70
FLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPV     71 - 140
DILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVS    141 - 210
LKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGL    211 - 280
YGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF                      281 - 332
//

Text Mined References (155)

PMID Year Title